Herpes Simplex Virus Type 1 Transcription during Latent Infections of Mouse and Man

Implications for Dementia
  • Anne M. Deatly
  • Ashley T. Haase
  • Melvyn J. Ball


Latent herpesvirus infections are generally described to have three stages: establishment, maintenance, and reactivation. Since 1929 when Goodpasture postulated that latent herpesvirus infections are established in the nervous system, we have known the sites where latent infections are established but the events by which latent infections are established, maintained, and reactivated remain a mystery. To completely understand the latency phenomena of herpesviruses, we must understand not only the role of the virus during the latent infection, but also the contribution of the infected cell or tissue to this process.


Herpes Simplex Herpes Simplex Virus Type Temporal Lobe Epilepsy Trigeminal Ganglion Latent Infection 
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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Anne M. Deatly
    • 1
  • Ashley T. Haase
    • 2
  • Melvyn J. Ball
    • 3
  1. 1.Department of MicrobiologyMount Sinai School of MedicineNew YorkUSA
  2. 2.Department of MicrobiologyUniversity of MinnesotaMinneapolisUSA
  3. 3.Department of Pathology, Clinical Neurological Sciences, and PsychiatryUniversity of Western OntarioLondonCanada

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