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Suppressive Effect of Alcohol on Normal Lymphocyte Proliferative Response to HIV Antigens

  • Madhavan P. N. Nair
  • Stanley A. Schwartz
  • Ziad A. Kronfol
  • Raveendran Pottathil
  • Edgar P. Heimer
  • John F. Greden

Abstract

Previous studies have shown that chronic alcohol intake is associated with abnormalities of humoral and cellular immune functions (Mutchnick and Lee, 1988; McKeever et al., 1988). Infection by the human immunodeficiency virus (HIV) causes profound dysfunction of cellular and humoral immune responses (Rosenberg and Fauci, 1989). Recent studies suggest that several cofactors such as other coincident infections, malnutrition, use of recreational drugs such as marijuana, cocaine, alcohol, and the like may exist in the natural history of HIV infection and development of AIDS. The present investigation is based on the hypothesis that alcohol may reduce the host’s immune response to HIV infection and increase the progression of the disease to clinical AIDS. We examined the effect of alcohol on natural killer (NK) cell activities and lymphocyte proliferative response (LPR) of lymphocytes from normal donors to peptides derived from the HIV.

Keywords

Human Immunodeficiency Virus Natural Killer Human Immunodeficiency Virus Infection Peripheral Blood Lymphocyte Natural Killer Cell Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Madhavan P. N. Nair
    • 1
  • Stanley A. Schwartz
    • 2
  • Ziad A. Kronfol
    • 3
  • Raveendran Pottathil
    • 4
  • Edgar P. Heimer
    • 4
  • John F. Greden
    • 3
  1. 1.Departments of Pediatrics, Epidemiology, and Psychiatry, the Alcohol Research Center, and Midwest AIDS Biobehavioral Research CenterUniversity of MichiganAnn ArborUSA
  2. 2.Departments of Pediatrics and Epidemiology, the Alcohol Research Center, and Midwest AIDS Biobehavioral Research CenterUniversity of MichiganAnn ArborUSA
  3. 3.Department of Psychiatry, the Alcohol Research Center, and Midwest AIDS Biobehavioral Research CenterUniversity of MichiganAnn ArborUSA
  4. 4.Hoffman-LaRoche, Inc.NutleyUSA

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