Immune Modulation in Major Depressive Patients in Remission
Compromised immunologic function has been demonstrated in psychological stress, bereavement, and depression (Calabrese et al., 1987). Lymphocyte function has been assessed in vitro by proliferative response to nonspecific mitogenic agents such as phytohemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM), yielding blunted stimulation with the three mitogens in the bereaved subjects (Bartrop et al.,1977; Schleifer et al., 1983). In addition, Schleifer et al. (1983) studied prospectively bereaved individuals for white blood cell counts and T and B lymphocyte subpopulations and found no changes in the parameters tested.
KeywordsMajor Depressive Disorder Immune Modulation Lithium Treatment Lymphocyte Subpopulation Depressive Illness
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