Immune Modulation in Major Depressive Patients in Remission

  • Eli Kritschmann
  • Daniel Becker
  • Susy Floru
  • Tamar Gotlieb-Stematsky


Compromised immunologic function has been demonstrated in psychological stress, bereavement, and depression (Calabrese et al., 1987). Lymphocyte function has been assessed in vitro by proliferative response to nonspecific mitogenic agents such as phytohemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM), yielding blunted stimulation with the three mitogens in the bereaved subjects (Bartrop et al.,1977; Schleifer et al., 1983). In addition, Schleifer et al. (1983) studied prospectively bereaved individuals for white blood cell counts and T and B lymphocyte subpopulations and found no changes in the parameters tested.


Major Depressive Disorder Immune Modulation Lithium Treatment Lymphocyte Subpopulation Depressive Illness 
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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Eli Kritschmann
    • 1
  • Daniel Becker
    • 1
  • Susy Floru
    • 1
  • Tamar Gotlieb-Stematsky
    • 1
  1. 1.Department of Psychiatry and The Central Virology Laboratory, Chaim Sheba Medical CenterTel-Aviv University, Sackler School of MedicineTel-HashomerIsrael

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