Interferon and Immunoglobulin G as Immunological Markers in Chronic Schizophrenia

  • Darrell G. Kirch
  • Richard Jed Wyatt

Abstract

The hypothesis that the etiology of schizophrenia may involve a viral infection is certainly not new (Menninger, 1926). One refinement of the hypothesis has led to the concept that the disorder may involve an abnormal immune response, such as production of a central nervous system (CNS) autoantibody, perhaps following exposure to viral antigens (Knight, 1982). While the viral/immunologic hypothesis has generated decades of research, these investigations have failed to yield definitive evidence to support or refute the concept (DeLisi and Crow, 1986; Torrey and Kaufmann, 1986). Nevertheless, the rapid advances being made in understanding the molecular processes involved in viral pathogenesis and immune regulation are presenting dramatic new opportunities to test this hypothesis.

Keywords

Permeability Albumin Dementia Influenza Schizophrenia 

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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Darrell G. Kirch
    • 1
  • Richard Jed Wyatt
    • 1
  1. 1.Neuropsychiatry Branch, Intramural Research ProgramNational Institute of Mental HealthUSA

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