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Interferon Production in Acute Psychiatric Disorders

  • Heikki Katila
  • Ranan Rimón
  • Kari Cantell
  • Björn Appelberg
  • Heikki Nikkilä

Abstract

Interferons (IFNs) have marked antiviral, cytostatic, and immunomodulatory activities and represent potent modulators of several cell membrane functions including regulation of the excitability of neurons (De Maeyer and De MaeyerGuignard, 1988). Changes in the production of these mediators may result in disturbed function of immune responses as well as neuronal transmission mechanisms.

Keywords

International Unit Sendai Virus Interferon Production Disturbed Function National Public Health Institute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bartrop, R. W., Luckhurst, E., Lazarus, L., Kiloh, L. G., and Penny, R., 1977, Depressed lymphocyte function after bereavement, Lancet 2: 834–836.CrossRefGoogle Scholar
  2. Cantell, K., Hirvonen, S., Kauppinen, H. L., and Myllylä, G., 1981, Production of interferon in human leukocytes from normal donors with the use of Sendai virus, Methods Enzymol. 78: 29–38.PubMedCrossRefGoogle Scholar
  3. Cantell, K., Hirvonen, S., and Kauppinen, H. L., 1986, Production and partial purification of human immune interferon, Methods Enzymol. 119: 54–63.PubMedCrossRefGoogle Scholar
  4. Chang, S., and Rasmussen, A. F., 1965, Stress induced suppression of interferon production in virus–infected mice, Nature 205: 623–624.CrossRefGoogle Scholar
  5. De Maeyer, E., and De Maeyer–Guignard, J., 1988, Interferons and Other Regulatory Cytokines, Wiley, New York.Google Scholar
  6. Glaser, R., Kiecolt–Glaser, J. K., Stout, J. C., Tarr, K., Speicher, C. E., and Holliday, J. E., 1985, Stress–related impairments in cellular immunity, Psychiatr. Res. 16: 233–239.Google Scholar
  7. Glaser, R., Rice, J., Speicher, C. E., Stout, J. C., and Kiecolt–Glaser, J. K., 1986, Stress depresses interferon production by leukocytes concomitant with a decrease in natural killer cell activity. Behan Neurosci. 100: 675–678.CrossRefGoogle Scholar
  8. Irwin, M., Daniels, M., Bloom, E. T., Smith, T. L., and Weiner, H., 1987, Life events, depressive symptoms and immune function, Am. J. Psychiatry 144: 437–441.PubMedGoogle Scholar
  9. Jensen, M. M., 1968, Transitory impairment of interferon production in stressed mice, J. Infect. Dis. 118: 230–234.PubMedCrossRefGoogle Scholar
  10. Katila, H., Cantell, K., Hirvonen, S., and Rimdn, R., 1989, Production of interferon alpha and gamma by leukocytes from patients with schizophrenia, Schiz. Res. 2: 361–365.Google Scholar
  11. Kiecolt—Glaser, J. K., Fisher, D., Georges, J., Messick, G., Speicher, C. E., and Glaser, R., 1987,Marital quality, marital disruption, and immune function, Psychosom. Med. 49:13–34.PubMedGoogle Scholar
  12. Mendelson, J., and Glascow, L. A., 1966, The in vitro and in vivo effects of corticol on interferon production and action, J. Inununol. 96: 345–349.Google Scholar
  13. Moises, H. W, Schindler, L., Leroux, M., and Kirchner, H., 1985, Decreased production of interferon alpha and interferon gamma in leukocyte cultures of schizophrenic patients, Acta Psychiatr. Scand. 72: 45–50.Google Scholar
  14. Palmblad, J., Cantell, K., Strander, H., Fröberg, J., Karlsson, C. G., and Levi, L., 1974, Stressor exposure and human interferon production, Reports from Laboratory for Clinical Stress Research, Department of Medicine and Psychiatry, Karolinska sjukhuset, Stockholm, No. 35.Google Scholar
  15. Palmblad, J., Cantell, K., Strander, H., Fröberg, J., Karlsson, C. G., Levi, L., Granström, M., and Unger, M., 1976, Stressor exposure and immunological response in man: Interferon–producing capacity and phagocytosis, J. Psychosom. Res. 20: 193–199.PubMedCrossRefGoogle Scholar
  16. Pavlidis, N., and Chirigos, M., 1980, Stress–induced impairment of macrophage tumoricidal function, Psychosom. Med. 42: 47–54.Google Scholar
  17. Schleifer, S. J., Keller, S. E., Siris, S. G., Davis, K. L., and Stein, M., 1985, Depression and immunity, Arch. Gen. Psychiatry 42: 129–133.CrossRefGoogle Scholar
  18. Solomon, G. F., Merigan, T. C., and Levine, S., 1967, Variation in adrenal cortical hormones within physiologic ranges, stress, and interferon production in mice, Proc. Soc. Exp. Biol. Med. 126: 74–79.Google Scholar

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Heikki Katila
    • 1
  • Ranan Rimón
    • 1
  • Kari Cantell
    • 2
  • Björn Appelberg
    • 1
  • Heikki Nikkilä
    • 1
  1. 1.Department of PsychiatryUniversity of HelsinkiHelsinkiFinland
  2. 2.National Public Health InstituteHelsinkiFinland

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