Lymphocyte Subsets in Schizophrenic Patients

  • Cinzia Masserini
  • Pasquale Ferrante
  • Antonio Vita
  • Carlo Lorenzo Cazzullo


Several immune system abnormalities have been described in schizophrenic patients. Evidence for the presence of antibrain antibodies in serum (LehmannFacius, 1937), morphological changes of lymphocytes (Hirata-Hibi et al., 1982), abnormal distribution of serum and CSF immunoglobulins (Zarrabi et al., 1979; DeLisi et al., 1984), decreased in vitro function of lymphocytes (Vartanian et al., 1978) and of natural killer cells (DeLisi et al., 1983), and deficient Interleukin-2 production (Villemain et al., 1989) have been reported. With regard to the distribution of lymphocyte subsets in peripheral blood, there is evidence either of T suppressor cell decrease (Muller et al., 1987; Kolyaskina et al.,1987), or of T helper increase (Ganguli et al., 1987), or of T total, T suppressor, and B lymphocyte increase (DeLisi and Wyatt, 1982), or of no changes at all (Kaufmann et al., 1987; Villemain et al., 1987, 1989).


Schizophrenic Patient Lymphocyte Subset Illness Onset Schizoid Disorder Subacute Sclerosing Panencephalitis 
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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Cinzia Masserini
    • 1
  • Pasquale Ferrante
    • 2
  • Antonio Vita
    • 1
  • Carlo Lorenzo Cazzullo
    • 1
  1. 1.Institute of Clinical PsychiatryUniversity of MilanMilanItaly
  2. 2.Multiple SclerosisUniversity Center “Don C. Gnocchi”MilanItaly

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