Predicting the Ecological Significance of Exposure to Genotoxic Substances in Aquatic Organisms
The effects of genotoxic substances are not adequately considered in aquatic ecological hazard assessment, and comparatively little has been done to develop methods for predicting these effects. It would be short sighted to ignore the potential for detrimental ecological impacts resulting from the disposal of genotoxic substances in aquatic environments. Advancements in this area must use our extensive knowledge of the mechanisms of effect of genotoxic substances in mammals, recognizing the factors that are unique to aquatic ecotoxicology. Because so much is known about basic mechanisms of effect and methods for evaluating the effects of genotoxic substances in mammals, this information must be applied to other species. However, as the methods for evaluating genotoxic effects in aquatic organisms are developed, we must go beyond method development and attempt to predict ecologically significant impacts from data on genotoxic responses. To accomplish this goal, fundamental processes that elucidate both similarities and differences in responses between or among species must be identified, and unifying concepts that may aid in predicting genotoxic effects in varied species must be formulated.
KeywordsReproductive Success Brood Size Genotoxic Effect Sister Chromatid Exchange Reproductive Effect
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