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Dna-Carcinogen Adducts in Fish as a Tool for Measuring the Effective Biological dose of Aquatic Carcinogens

  • Bruce P. Dunn
Part of the Environmental Science Research book series (ESRH, volume 38)

Abstract

The majority of chemical carcinogens act by inducing genetic damage in cells. The most common type of such damage results when the carcinogen (or its metabolite) covalently binds to DNA, forming a DNA-carcinogen adduct. Such adducts are generally thought to be relatively benign in nondividing cells, and may be removed from the DNA by a variety of enzymatic DNA repair mechanisms. However, if repair is not complete when cells with DNA-carcinogen adducts attempt to divide, the damaged DNA may be used as a template for DNA synthesis. Attempts to replicate adducted DNA can lead to a variety of types of heritable genetic damage, including point mutations, deletions, insertions and translocations. Such mutations are capable of activating oncogenes and producing cells that are genetically programmed to form a neoplasm.

Keywords

Polycyclic Aromatic Hydrocarbon Effective Biological Dose Genetic Damage Adduct Level Environmental Carcinogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Dunn, B.P., 1989, Carcinogen adducts as an indicator for the public health risks of consuming carcinogen-exposed fish and shellfish, Environ. Health Perspect. (in press).Google Scholar
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Bruce P. Dunn
    • 1
  1. 1.British Columbia Cancer Research CentreVancouverCanada

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