Analytical Epidemiology in Pet Populations for Environmental Risk Assessment

  • Lawrence T. Glickman
Part of the Environmental Science Research book series (ESRH, volume 38)


There is a critical need to assess the potential impact on animal and human health of the estimated 70,000 man-made chemicals already in the environment and the approximately 1,000 new chemicals released each year (Hollstein et al., 1979). The process by which the potential adverse health effects of exposures to environmental contaminants are determined is called risk assessment. Risk assessment involves an evaluation of the results of epidemiologic, clinical, toxicologic, and environmental research, and extrapolation of the findings to predict the type, and estimate the extent, of health effects under given conditions of exposure (National Research Council, 1983). Inherent to the process is characterization of the uncertainties of the resulting estimates.


Risk Assessment Chemical Contaminant Human Health Risk Assessment Insecticide Exposure American Veterinary Medical Association 
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  1. American Veterinary Medical Association, 1988, Supply and demand: the chicken or the egg syndrome? Marketing and Practice Strategies for Companion Animal Practitioners, 1: 1.Google Scholar
  2. Buck, W.B., 1979, Animals as monitors of environmental quality, Vet. Hum. Toxicol., 21: 277–284.Google Scholar
  3. Cypess, R.H., and Hurvitz, A.I., 1974, Animal models, in: “The Handbook of Laboratory Animal Science,” E.C. Melby and H.H. Altman, eds., CRC Press, Cleveland, OH, pp.Google Scholar
  4. Glickman, L.T., Domanski, L.M., Maguire, T.G., Dubielzig, R.R., and Churg,A., 1983, Mesothelioma in pet dogs associated with exposure of their owners to asbestos, Environ. Res., 32: 305–313.Google Scholar
  5. Glickman, L.T., Shofer, F.S., McKee, L.J., Reig, J.S., Goldschmidt, M.H., 1990, An epidemiologic study of insecticide exposures, obesity, and risk of bladder cancer in household dogs, J. Toxicol. Environ. Hlth. (In press).Google Scholar
  6. Hoel, D., and Hogan, M., 1988, Estimation of population risks, in: “Report of the Subcommittee on Health Effects, Research Strategies Committee, Appendix D: Strategies for Health Effects Research,” Y.S. Environmental Protection Agency, Washington, D.C.Google Scholar
  7. Hollstein, M., McCann, J., Angelosanto, F.A., and Nichols, N.N., 1979, Short-term tests for carcinogens and mutagens, Mutat. Res., 65:133–226. Kendall, R.J., 1988, Wildlife toxicology: A reflection on the past and the challenge of the future, Environ. Toxicol. Chem., 7: 337–338.Google Scholar
  8. MacVean, D.W., Monlux, A.W., Anderson, P.S., Solberg, S.L., and Roszel, J.F., 1978, Frequency of canine and feline tumors in a defined population, Vet. Pathol., 15: 700–715.Google Scholar
  9. Matanoski, G.M., and Elliott, E.A., 1981, Bladder cancer epidemiology, Epidemiol. Rev., 3: 203–229.Google Scholar
  10. McDonald, J.C., and McDonald, A.D., 1977, Epidemiology of mesothelioma from estimated incidence, Prev. Med., 6: 426–446.Google Scholar
  11. National Research Council, National Academy of Sciences, Committee on the Institutional Means for Assessment of Risks to Public Health, 1983, Risk Assessment in the Federal Government: Managing the Process, Washington, D.C.Google Scholar
  12. National Research Council, National Academy of Sciences, Committee on the Animals as Monitors of Environmental Health Hazards, 1989, Early Warnings: Animal Sentinels of Environmental Health Hazards, Washington, D.C., (In press).Google Scholar
  13. Schneider, R., 1975, A population based animal tumor registry, in: “Animal Disease Monitoring,” D.G. Ingram, W.R., Mitchell, and S.W. Martin, eds., Charles C. Thomas, Springfield, IL.Google Scholar
  14. Selikoff, I.J., Hammond, E.C., and Seidman, H., 1980, Latency of asbestos disease among insulation workers in the United States and Canada, Cancer, 46: 2736–2740.PubMedCrossRefGoogle Scholar
  15. Shannon, R.E., 1975, “Systems Simulation,” Prentice Hall, Englewood Cliffs, NJ, pp.l-35.Google Scholar
  16. Shofer, F.S., Sonnenschein, E.G., Goldschmidt, M.H., Laster, L.L., and Glickman, L.T., 1989, Histopathologic and dietary prognostic factors for canine mammary carcinoma, Breast Cancer Res. Treat., 13: 49–60.Google Scholar
  17. Tjalma, R.A., Puester, W.A., Adelstein, E.H., and Vander Zwagg, R., 1964, Clinical records systems and data retrieval function in veterinary medicine, A proposal for systematic data programming, J. Amer. Vet. Med. Assoc., 145: 1189–1197.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Lawrence T. Glickman
    • 1
  1. 1.Department of Pathobiology School of Veterinary MedicinePurdue UniversityWest LafayetteUSA

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