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The Role of Phospholipase A2 Activating Protein (PLAP) in Regulating Prostanoid Production in Smooth Muscle and Endothelial Cells Following Leukotriene D4 Treatment

  • Mike A. Clark
  • John S. Bomalaski
  • Theresa M. Conway
  • Mike Cook
  • Janice Dispoto
  • Seymore Mong
  • Robert G. L. Shorn
  • Jeff Stadell
  • Lynne Webb
  • Stanley T. Crooke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 275)

Abstract

Leukotrienes are a family of compounds originally termed the slow-reacting substances of anaphylaxis and are recognized as important mediators of anaphylaxis (1). In particular, leukotriene C4 (LTC4 ) and leukotriene D4 (LTD4) are potent spasmogens in a variety of smooth muscle tissues including trachea, lung, ileum and the vasculature (2.4). The mechanism by which contraction is induced by the leukotrienes (LTs) is not yet known. However, in some experimental systems, but not all, a cyclooxygenase product of arachidonic acid metabolism, possibly thromboxane B2 (TxB2 ), may be involved in mediating leukotrieneinduced effects (3,4). This is based on the observation that inhibitors of cyclooxygenase, such as indomethacin and meclofenamic acid, can block leukotriene-induced contraction of the lung parenchyma, vasculature and the ileum (2.4). In other tissues, most notably guinea pig trachea, the cyclooxygenase products appear to be relatively unimportant mediators of leukotriene effects (5). Furthermore, in the tissues in which cyclooxygenase products appear to be important, thromboxane synthesis may be crucial for the leukotriene responses (4). Although TxB2 is usually assumed to be of platelet origin, the cellular source of LT-induced thromboxane synthesis is not known.

Keywords

Arachidonic Acid Phospholipase Activity Cyclooxygenase Product Prostacyclin Synthesis PROSTANOID Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Mike A. Clark
    • 1
    • 2
  • John S. Bomalaski
    • 1
    • 3
  • Theresa M. Conway
    • 1
  • Mike Cook
    • 1
  • Janice Dispoto
    • 1
  • Seymore Mong
    • 1
  • Robert G. L. Shorn
    • 1
    • 4
  • Jeff Stadell
    • 1
  • Lynne Webb
    • 1
    • 2
  • Stanley T. Crooke
    • 1
  1. 1.Smith Kline and FrenchPhiladelphiaUSA
  2. 2.Washington University School of MedicineSt. LouisUSA
  3. 3.Veterans Administration Medical CenterMedical College of PennsylvaniaPhiladelphiaUSA
  4. 4.AT BiochemMalvernUSA

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