Mobilization and Function of Extracellular Phospholipase A2 in Inflammation

  • Jerrold Weiss
  • Grace Wright
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 275)


A common characteristic of inflammatory exudates is the accumulation of relatively high concentrations of phospholipase A2 (PLA-2) in the cell-free fluid (1). Because many (by-)products or this enzyme’s action can exert pro-inflammatory effects (e.g. eicosanoid derivatives of arachidonic acid), these observations have prompted considerable speculation about the possible (patho-) physiological role of extracellular PLA-2 in inflammation. These ideas, in turn, have triggered many investigators and pharmaceutical companies alike to search for “specific” inhibitors of PLA-2 that could be applied therapeutically in acute or chronic inflammatory diseases.


Ascitic Fluid Inflammatory Exudate Primary Structure Analysis Extracellular Phospholipase Rabbit Peritoneal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Jerrold Weiss
    • 1
  • Grace Wright
    • 1
  1. 1.Departments of Microbiology and MedicineNew York University School of MedicineNYUSA

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