Clinical Considerations for Neutron Capture Therapy of Brain Tumors
In welcoming this Workshop on Neutron Capture Therapy to Boston, it would be appropriate to reflect upon the fact that, at the turn of the century, Boston was a major center for the development and use of x-rays to cure cancer. This was summarized by Dr. Francis H. Williams in his book entitled, “The Roentgen Rays in Medicine and Surgery as an Aid in Diagnosis and as a Therapeutic Agent,” published in 1901. Dr. Williams published some of the first photographs documenting the curative potential of the then newly discovered x-rays for the treatment of skin cancers. In the ensuing decades, the science and technology of ionizing radiation has been developed and expanded to effectively treat a wide variety of tumors. For many, radiation therapy as a primary or adjuvant treatment either leads to cure of their disease or is a highly effective means of palliation. However, the results of even modern radiotherapy for the management of primary brain tumors and tumor metastases to the brain from primaries arising elsewhere in the body have been extremely disappointing. In spite of significant advances in our understanding of tumor biology and technical advances in radiation delivery, the results of radiotherapy for these tumors have not changed significantly during the past twenty years. We are, therefore, very excited at the potential clinical impact of neutron capture therapy (NCT).
KeywordsNeutron Beam Primary Brain Tumor Boron Neutron Capture Therapy Boron Compound Integral Dose
Unable to display preview. Download preview PDF.
- 1.V. Levin, G. Sheline, and P. Gutin, “Neoplasms of the Central Nervous System,” in Cancer: Principles and Practice of Oncology, 3rd Ed., V. DeVita, S. Hellman, and S. Rosenberg, eds., Lippincott, Philadelphia, p. 1557 (1989).Google Scholar
- 4.C. Daumas-Duport, B. W. Scheithauer, and P. J. Kelly, “A Histologic and Cytologic Method for the Spatial Definition of Gliomas,” Mayo Clinic Proc., 62: 435 (1989).Google Scholar
- 6.R. G. Zamenhof, W. S. Schoene, G. L. Brownell, G. R. Wellum, H. Hatanaka, A. Takeuchi, and M. Shalev, “An Investigation of the Tolerance of Canine Brain to Thermal Neutron Capture Therapy.” (In Preparation.)Google Scholar
- 7.J. Deacon, M. J. Peckham, and G. G. Steel, “The Radioresponse of Human Tumors on the Initial Slope of the Cell Survival Curve,” Radiother. Oncol., 2:317 (1984).Google Scholar
- 9.E. J. Hall, Radiobiology for the Radiologist, 3rd Ed., Lippincott, Philadelphia, PA (1988).Google Scholar