Biomedical Irradiation System for Boron Neutron Capture Therapy at the Kyoto University Reactor
Physics studies related to radiation source, spectroscopy, beam quality, dosimetry, and biomedical applications using the Kyoto University Reactor Heavy Water Facility are described. Also, described are a Nickel Mirror Neutron Guide Tube and a Super Mirror Neutron Guide Tube that are used both for the measurement of boron concentration in phantom and living tissue and for precise measurements of neutron flux in phantom in the presence of both light and heavy water. Discussed are: (1) spectrum measurements using the time of flight technique, (2) the elimination of gamma rays and fast neutrons from a thermal neutron irradiation field, (3) neutron collimation without producing secondary gamma rays, (4) precise neutron flux measurements, dose estimation, and the measurement of boron concentration in tumor and its periphery using guide tubes, (5) the dose estimation of boron-10 for the first melanoma patient, and (6) special-purpose biological irradiation equipment. Other related subjects are also described.
KeywordsThermal Neutron Heavy Water Boron Concentration Boron Neutron Capture Therapy Neutron Fluence
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- 2.K. Kanda, T. Kobayashi, K. Ono, T. Sato, T. Shibata, Y. Ujeno, Y. Mishima, H. Hatanaka, and Y. Nishiwaki, “Elimination of Gamma Rays from a Thermal Neutron Field for Medical and Biological Irradiation Purposes,” IAEA-SM-193/68, IAEA, Vienna, Austria, March 10–14, 1975, Biomedical Dosimetry, p. 205.Google Scholar
- 3.T. Kobayashi, T. Kozuka, H. Chatani, K. Kanda, and T. Shibata, “Experimental Study on Increase of Thermal Neutron Flux in the KUR Heavy Water Facility for Effective Use of Exposure Tubes and a U-235 Fission Converter,” Annu. Rep. Res. Reactor Inst. Kyoto Univ., 18:133 (1985).Google Scholar
- 4.S. Okamoto, T. Akiyoshi et al., “KUR Neutron Guide Tube,” Kyoto University Research Reactor Institute (1974).Google Scholar
- 7.M. Ono, T. Kobayashi, and K. Kanda, “Improvement of Calculation Technique on Flux Distribution in a Water Phantom Caused by Narrow Thermal Neutron Beam for Neutron Capture Therapy,” Annu. Rep. Res. Reactor Inst. Kyoto Univ., 21:102 (1988).Google Scholar
- 10.T. Ebisawa, T. Akiyoshi, S. Tasaki, T. Kawai, N. Achiwa, M. Uturo, and S. Okamoto, “Nickel Mirror and Super Mirror Neutron Guide Tubes at the Kyoto University Research Reactor,” in Thin-Film Neutron Optical Devices, SPIE, Vol. 983, p. 54 (1988).Google Scholar
- 11.K. Kanda, T. Kobayashi, M. Takeuchi, and S. Ouchi, “Development of Neutron Shielding Material Using LiF,” Proc. Sixth Int. Conf. on Radiation Shielding Vol. II, JAERI, Tokyo, Japan, p. 1258 (1983).Google Scholar
- 12.T. Kobayashi, M. Ono, and K. Kanda, “Measurement and Analysis on Neutron Flux Distributions in a Heavy Water Phantom Using the KUR Neutron Guide Tube for BNCT,” Strahlenther. Onkol. 165(2/3):101(1989).Google Scholar
- 13.T. Hamada, K. Aoki, T. Kobayashi, and K. Kanda, “The in vivo Measurement of the Time-Dependent 10B Movement in Tumor of Hamsters,” Annu. Rep. Res. Reactor Inst. Kyoto Univ., 16:112 (1983).Google Scholar
- 14.Y. Ujeno, O. Niwa, K. Takimoto, K. Kanda, T. Kobayashi, and K. Ono, “Distributions of Thermal Neutrons and Gamma Rays in CO2 Incubators Set in Thermal Neutron Field for Medical and Biological Irradiation Purposes,” in Proc., Sixth Int. Congress of Radiat. Res., Tokyo, Japan, A-30–1 (1979).Google Scholar
- 15.M. R. Ishida, K. Kanda, T. Kobayashi, and Y. Ujeno, “Organization and Facilities for Boron Neutron Capture Therapy in KURRI,” in Proc. Second Japan-Australia Int. Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, Japan, III - 2 (1987).Google Scholar
- 17.T. Kobayashi and K. Kanda, ‘Boron-10 Dosage in Cell Nucleus for Neutron Capture Therapy - Boron Selective Dose Ratio,“ in Boron Neutron Capture Therapy for Tumors, H. Hatanaka, ed., Chapter XXII, Nishimura Co., Ltd., Niigata, Japan, p. 293 (1986).Google Scholar