Abstract
Monte Carlo based dosimetry and computer-aided treatment planning for neutron capture therapy have been developed to provide the necessary link between physical dosimetric measurements performed on the MITR-II epithermal-neutron beams and the need of the radiation oncologist to synthesize large amounts of dosimetric data into a clinically meaningful treatment plan for each individual patient. Monte Carlo simulation has been employed to characterize the spatial dose distributions within a skull/brain model irradiated by an epithermal-neutron beam designed for neutron capture therapy applications. The geometry and elemental composition employed for the mathematical skull/brain model and the neutron and photon fluence-to-dose conversion formalism are presented. A treatment planning program, NCTPLAN, developed specifically for neutron capture therapy, is described. Examples are presented illustrating both one and two-dimensional dose distributions obtainable within the brain with an experimental epithermal-neutron beam, together with beam quality and treatment plan efficacy criteria which have been formulated for neutron capture therapy. The incorporation of three-dimensional computed tomographic image data into the treatment planning procedure is illustrated. The experimental epithermal-neutron beam has a maximum usable circular diameter of 20 cm, and with 30 ppm of B-10 in tumor and 3 ppm of B-10 in blood, it produces (with RBE weighting) a beam-axis advantage depth of 7.4 cm, a beam-axis advantage ratio of 1.83, a global advantage ratio of 1.70, and an advantage depth RBE-dose rate to tumor of 20.6 RBE-cGy/min (cJ/kg-min). These characteristics make this beam well suited for clinical applications, enabling an RBE-dose of 2,000 RBE-cGy/min (cJ/kg-min) to be delivered to tumor at brain midline in six fractions with a treatment time of approximately 16 minutes per fraction. With parallel-opposed lateral irradiation, the planar advantage depth contour for this beam (with the B-10 distribution defined above) encompasses nearly the whole brain. Experimental calibration techniques for the conversion of normalized to absolute treatment plans are described.
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References
G. L. Brownell, R. G. Zamenhof, B. W. Murray, and G. R. Wellum, “Boron Neutron Capture Therapy,” in Therapy in Nuclear Medicine, R. P. Spencer, ed., Grime and Stratton, Inc., New York (1978).
Proc. Third Int. Symp. on Neutron Capture Therapy, Strahlenther. Onkol., D. Gabel, ed., 165(2/3):5–257 (1989).
G. L. Locher, “Biologic Effects and Therapeutic Possibilities of Neutrons,” Am. J. Roentgenol., 36:1 (1936).
H. Hatanaka, “Clinical Experience of Boron-Neutron Capture Therapy for Gliomas — A Comparison with Conventional Chemo-Immuno-Radiotherapy,” in Boron-Neutron Capture Therapy for Tumors, H. Hatanaka, ed., Nishimura Co., Ltd., Niigata, Japan, p. 349 (1986).
A. H. Soloway, “Chemical Aspects of Neutron Capture Therapy,” in Radionuclide Applications in Neurology and Neurosurgery, Y. Wang and P. Paoletti, eds., Charles Thomas, Springfield, IL (1970).
R. G. Fairchild, “Development and Dosimetry of an ‘Epithermal’ Neutron Beam for Possible Use in Neutron Capture Therapy, ” Phys. Med. Biol., 10 (4): 491 (1965).
R. G. Zamenhof, B. W. Murray, G. L. Brownell, G. R. Wellum, and E. I. Tolpin, “Boron Neutron Capture Therapy for the Treatment of Cerebral Gliomas: I. Theoretical Evaluation of the Efficacy of Various Neutron Beams,” Med. Phys., 2(2):47 (1975).
R. G. Fairchild and V. P. Bond, “Current Status of B-10 Neutron Capture Therapy: Enhancement of Tumor Dose via Beam Filtration and Dose Rate, and the Effects of these Parameters on Minimum Boron Content: A Theoretical Evaluation,” Int. J. Radiat. Oncol. Biol. Phys., 11(4):831 (1985).
O. K. Harling, S. D. Clement, J. R. Choi, J. A. Bernard, and R. G. Zamenhof, “Neutron Beams for Neutron Capture Therapy at the MIT Research Reactor,” Strahlenther. Onkol., 165(2/3):90 (1989).
R. G. Zamenhof, S. D. Clement, K. Lin, C. Lui, D. Ziegelmiller, and O. K. Harling, “Monte Carlo Treatment Planning and High-Resolution Alpha-Track Autoradiography for Neutron Capture Therapy,” Strahlenther. Onkol., 165(2/3): 188 (1989).
R. G. A. Zamenhof, H. Madoc-Jones, O. K. Harling, and J. A. Bernard, Jr., “Clinical Considerations in the Use of Thermal and Epithermal Neutron Beams for Neutron Capture Therapy,” in Proc. 1988 Workshop on Clinical Aspects of Neutron Capture Therapy, R.G. Fairchild, V. P. Bond, and A. D. Woodhead, eds., Basic Life Sciences Series, Vol. 50, Plenum Press, New York, p. 121 (1989).
J. R. Choi, S. D. Clement, O. K. Harling, and R. G. Zamenhof, “Neutron Capture Therapy Beams at the MIT Research Reactor.” (These Proceedings.)
S. D. Clement, J. R. Choi, R. G. Zamenhof, and O. K. Harling, “Monte Carlo Methods of Neutron Beam Design for Neutron Capture Therapy at the MIT Research Reactor (MTTR-II).” (These Proceedings.)
G. R. Wellum, R. G. Zamenhof, and E. I. Tolpin, “Boron Neutron Capture Radiation Therapy of Cerebral Gliomas: An Analysis of the Possible Use of Boron-Loaded Tumor-Specific Antibodies for the Selective Concentration of Boron in Gliomas,” Int. J. Radiat. Oncol. Biol. Phys., 8(8):1339 (1983).
T. Matsumoto and O. Aizawa, “Depth-Dose Evaluations and Optimization of the Irradiation Facility for Boron Neutron Capture Therapy of Brain Tumors,” Phys. Med. Biol 30(9):897 (1985).
J. F. Briesmeister, ed., “MCNP — A General Monte Carlo Code for Neutron and Photon Transport, Version 3A,” Los Alamos National Laboratory, LA-7396-M, Rev. 2 (1986).
W. S. Snyder, M. R. Ford, G. G. Warner, and H. L. Fisher, Jr., “Estimates for Absorbed Fractions for Monoenergetic Photon Sources Uniformly Distributed in Various Organs of a Heterogeneous Phantom,” MIRD, J. Nucl. Med., Suppl. No. 3, Pamphlet 5, p. 47 (1969).
B. W. Murray, O. L. Deutsch, R. G. Zamenhof, and G. L. Brownell, “New Approaches to the Dosimetry of Boron Neutron Capture Therapy at MIT-MGH,” in Biomedical Dosimetry, IAEA, Vienna (1975).
O. L. Deutsch, and B. W. Murray, “Monte Carlo Dosimetry Calculation for Boron Neutron Capture Therapy in the Treatment of Brain Tumors,” Nucl. Technol., 26:320 (1975).
R. A. Brooks, G. DiChiro, and M. R. Keller, “Explanation of Cerebral White-Gray Contrast in Computed Tomography,” J. Comp. Assist. Tomog., 4(4):489 (1980).
M. A. Weissberger, R. G. Zamenhof, S. Aronow, and R. M. Neer, “Computed Tomography Scanning for the Measurement of Bone Mineral in the Human Spine,” J. Comp. Assist. Tomog., 2:253 (1978).
E. Betz, “Cerebral Blood: Its Measurement and Regulation,” Physiological Reviews, 3: 595 (1972).
BNL-325, Suppl. No. 2, 6th Ed. (1988).
J. H. Hubbel, “Photon Mass Attenuation and Energy Absorption Coefficients from 1 KeV to 20 MeV,” Int. J. Appl. Rachat. Isot., 33:1269 (1982).
R. S. Caswell, J. J. Coyne, and M. L. Randolph, “KERMA Factors of Elements and Compounds for Neutron Energies Below 30 MeV,” Int. J. Appl. Radiat. Isot., 33:1227 (1982).
A. K. Asbury, R. Ojemann, and S. L. Nielsen, “Neuropathologic Study of Fourteen Cases of Malignant Brain Tumors Treated by Boron-10 Slow Neutron Capture Therapy,” J. Neuropathol. Exp. Neurol., 31:278 (1972).
L. E. Kun, “The Brain and Spinal Cord,” in Radiation Oncology: Rationale, Techniques, Results, W. T. Moss and J. D. Cox, eds., 6th Ed., C. V. Mosby Co., St. Louis, MO, p. 597 (1989).
K. Kitao, “Vascular Wall Dose from Boron Neutron Capture Reaction,” in Boron-Neutron Capture Therapy for Tumors, H. Hatanaka, ed., Nishimura Co., Ltd., Niigata, Japan, p. 191 (1986).
Rapporteurs’ Report. (These Proceedings.)
R. G. Zamenhof, W. C. Schoene, G. L. Brownell, G. R. Wellum, H. Hatanaka, A. Takeuchi, and M. Shalev, “An Investigation of the Tolerance of Canine Brain to Thermal Neutron Capture Therapy.” (In Preparation.)
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Zamenhof, R.G. et al. (1990). Monte Carlo Based Dosimetry and Treatment Planning for Neutron Capture Therapy of Brain Tumors. In: Harling, O.K., Bernard, J.A., Zamenhof, R.G. (eds) Neutron Beam Design, Development, and Performance for Neutron Capture Therapy. Basic Life Sciences, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5802-2_22
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DOI: https://doi.org/10.1007/978-1-4684-5802-2_22
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