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A Versatile, New Accelerator Design for Boron Neutron Capture Therapy: Accelerator Design and Neutron Energy Considerations

  • R. E. Shefer
  • R. E. Klinkowstein
  • J. C. Yanch
  • G. L. Brownell
Part of the Basic Life Sciences book series (BLSC, volume 54)

Abstract

The development of a new, compact high-current proton accelerator by Science Research Laboratory (SRL) capable of producing large quantities of neutrons fits closely with the recent interest in the use of epithermal neutrons for Boron Neutron Capture Therapy (BNCT). Three important facets of this development are currently being investigated. These include 1) the production of neutrons by the 7Li(p,n) reaction using a novel tandem cascade electrostatic accelerator, 2) the optimal neutron energy (or range of energies) for treatment of tumors at different depths in tissue, and 3) the extent of moderation and filtering required to reduce the energy of the accelerator neutrons to the energies deemed optimal in (2) above. The overall goal is to develop a versatile epithermalneutron source which will be, initially, a valuable research tool in the development of BNCT, and ultimately, an essential component of a hospital-based patient irradiation facility.

Keywords

Neutron Energy Neutron Beam Neutron Yield Boron Neutron Capture Therapy Epithermal Neutron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    V. N. Kononov and E. D. Yurlov, “Absolute Yield and Spectrum of Neutrons from the 7Li(p,n)7Be Reaction,” Soy. At. Energy, 43:947 (1977).CrossRefGoogle Scholar
  2. 2.
    H. Liskien and A. Paulsen, “Neutron Production Cross Sections and Energies for the Reactions 7Li(p,n)7Be and 7Li(p,n)7Be, ” Atomic Data and Nuclear Data Tables, 15: 57 (1975).CrossRefGoogle Scholar
  3. 3.
    J. H. Gibbons and H. W. Newson, “The Li7(p,n)Be7 Reaction,” in Fast Neutron Physics, Vol. 1, J. B. Marron and J. L. Fowler, eds., Int. Science, New York, p. 133 (1960).Google Scholar
  4. 4.
    G. L. Brownell, J. E. Kirsch, and J. Kehayias, “Accelerator Production of Epithermal Neutrons for Neutron Capture Therapy,” in Proc. Second Int. Symp. on Neutron Capture Therapy, Tokyo, 1985, H. Hatanaka, ed., Nishimura Co., Ltd., Niigata, Japan, p. 127 (1986).Google Scholar
  5. 5.
    C. K. Wang, T. E. Blue, and R. A. Gahbauer, “A Design Study of an Accelerator-Based Epithermal Neutron Source for Boron Neutron Capture Therapy,” Strahlenther. Onkol., 165(2/3):75 (1989).PubMedGoogle Scholar
  6. 6.
    C. K. Wang, T. E. Blue, and R. Gahbauer, “A Neutronic Study of an Accelerator-Based Neutron Irradiation Facility for Boron Neutron Capture Therapy,” Nucl. Technol., 84:93 (1989).Google Scholar
  7. 7.
    K. R. Kendall, M. McDonald, D. R. Mosscrop, P. W. Schmor, and D. Yuan, Rev. Sci. Instrum., 57:7 (1986).CrossRefGoogle Scholar
  8. 8.
    R. K. York, R. R. Stevens, Jr., R. A. DeHaven, J. R. McConnell, E. P. Chamberlin, and R. Kandarian, “The Development of a High Current H-Injector for the Proton Storage Ring at LAMPF,” Nucl. Instruments and Methods in Phys. Res., B10/11:891 (1985).Google Scholar
  9. 9.
    G. L. Brownell and W. H. Sweet, “Studies on Neutron Capture Therapy,” in Progress in Nuclear Energy Series VII. Vol. 2 - Medical Sciences, Pergamon Press, London, p. 114 (1959).Google Scholar
  10. 10.
    J. F. Briesmeister, ed., “MCNP — A General Monte Carlo Code for Neutron and Photon Transport, Version 3A,” Los Alamos National Laboratory, LA-7396-M, Rev. 2 (1986).Google Scholar
  11. 11.
    R. S. Caswell, J. J. Coyne, and M. L. Randolph, “KERMA Factors of Elements and Compounds for Neutron Energies Below 30 MeV,” Int. J. Appl. Radiat. Isot., 33:1227 (1982).CrossRefGoogle Scholar
  12. 12.
    R. G. Zamenhof, B. W. Murray, G. L. Brownell, G. R. Wellum, and E. I. Tolpin, “Boron Neutron Capture Therapy for the Treatment of Cerebral Gliomas: I. Theoretical Evaluation of the Efficacy of Various Neutron Beams,” Med. Phys., 2(2):47 (1975).PubMedCrossRefGoogle Scholar
  13. 13.
    D. I. Garber and R. R. Kinsey, Neutron Cross-Sections. Vol. II. Curves, Brookhaven National Laboratory, New York (1976).Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • R. E. Shefer
    • 1
  • R. E. Klinkowstein
    • 1
  • J. C. Yanch
    • 2
  • G. L. Brownell
    • 2
  1. 1.Science Research LaboratorySomervilleUSA
  2. 2.Department of Nuclear EngineeringMassachusetts Institute of TechnologyCambridgeUSA

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