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Installation and Testing of an Optimized Epithermal Neutron Beam at the Brookhaven Medical Research Reactor (BMRR)

  • R. G. Fairchild
  • J. Kalef-Ezra
  • S. K. Saraf
  • S. Fiarman
  • E. Ramsey
  • L. Wielopolski
  • B. H. Laster
  • F. J. Wheeler
Part of the Basic Life Sciences book series (BLSC, volume 54)

Abstract

Initial clinical trials of Neutron Capture Therapy (NCT) in the United States were unsuccessful. Lack of success has been attributed to two causes: (1) absence of selective localization of boron in tumor cells, and (2) poor penetration in tissue of the thermal-neutron beams used. Since then, improved compounds have been developed which can be selectively targeted to tumor [1–3]. In addition, improvements have been made in neutron delivery. At a workshop on neutron sources for NCT held in 1986, it was recommended that current technology be utilized to produce pure epithermal-neutron beams for NCT. These would provide the increased penetration in tissue required for improved therapy. The study group on neutron beams recommended that these beams should have an epithermal-neutron flux density of ~1×109 n/cm2-s (or more) to enable application of therapy within ~1 hour (or less) [4].

Keywords

Fast Neutron Neutron Beam Boron Neutron Capture Therapy Epithermal Neutron Brookhaven National Laboratory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • R. G. Fairchild
    • 1
  • J. Kalef-Ezra
    • 1
    • 2
  • S. K. Saraf
    • 1
  • S. Fiarman
    • 1
  • E. Ramsey
    • 3
  • L. Wielopolski
    • 3
  • B. H. Laster
    • 1
  • F. J. Wheeler
    • 4
  1. 1.Medical DepartmentBrookhaven National LaboratoryUptonUSA
  2. 2.University of IoanninaIoanninaGreece
  3. 3.Health Sciences CenterState University of New YorkStony BrookUSA
  4. 4.Idaho National Engineering LaboratoryIdaho FallsUSA

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