Progress Towards Boron Neutron Capture Therapy at the High Flux Reactor Petten
During 1988 the first positive steps were taken to proceed with the design and construction of a neutron capture therapy facility on the High Flux Reactor (HFR) at Petten. The immediate aim is to realise within a short time (summer 1989), an epithermal neutron beam for radiobiological and filter optimisation studies on one of the 10 small aperture horizontal beam tubes. The following summer, a much larger neutron beam, i.e., in cross section and neutron fluence rate, will be constructed on one of the two large beam tubes that replaced the old thermal column in 1984. This latter beam tube faces one whole side of the reactor vessel, extending from a 50 x 40 cm input aperture to a 35 x 35 cm exit hole. The radiotherapeutic facility will be housed here, with the intention to start clinical trials at the beginning of 1991.
This paper describes the present status of the project and includes: a general description of the pertinent characteristics with respect to NCT of the HFR; results of the recently completed preliminary neutron metrology and computer modeling at the input end of the candidate beam tube; the structure and planning of the proposed Work Programme; and the respective direct and indirect participation and collaboration with the Netherlands Cancer Institute and the European Collaboration Group on BNCT.
KeywordsNeutron Beam Neutron Spectrum Fluence Rate Boron Neutron Capture Therapy Netherlands Cancer Institute
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- 1.R. G. Zamenhof, H. Madoc-Jones, O. K. Harling, and J. A. Bernard, Jr., “A Multidisciplinary Program Leading to a Clinical Trial of Neutron Capture Therapy at Tufts – New England Medical Center and the Massachusetts Institute of Technology,”Strahlenther. Onkol“ 165 (2/3):254 (1989).Google Scholar
- 2.H. Roettger et al., “High Flux Materials Testing Reactor Petten, Characteristics of Facilities and Standard Irradiation Devices,” EUR 5700 EN (1986).Google Scholar
- 3.F. Stecher-Rasmussen, “Capture Gamma-Ray Spectroscopy and Related Topics,” in Proc. AIP Conf. No. 125, Knoxville, TN (1984).Google Scholar
- 4.R. W. A. Kraakman et al., “Neutron Fluence Rate and Neutron Spectrum Measurements in Front of HB 11 and JIB 12. (Part of a Feasibility Study for a BNCT Facility),” ECN-89–06 (1989).Google Scholar
- 5.The DOT 3.5 Two-Dimensional Discrete Ordinates Radiation Transport Code,“ Radiation Shielding Information Center, Oak Ridge National Laboratory (1976).Google Scholar
- 6.J. F. Breismeister, ed., “MCNP — A General Monte Carlo Code for neutron and photon transport, Version 3A” Los Alamos National Laboratory, LA-7396-M Rev. 2 (1986).Google Scholar