Neuroendocrine Responses to Emotional Stress: Possible Interactions Between Circulating Factors and Anterior Pituitary Hormone Release

  • J. L. Meyerhoff
  • M. A. Oleshansky
  • K. T. Kalogeras
  • E. H. Mougey
  • G. P. Chrousos
  • L. G. Granger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 274)


Anterior pituitary hormones released during stress have multiple direct and indirect effects in the periphery including mobilization of energy reserves (1) via gluconeogenesis and lipolysis (2, 3), effects on the cardiovascular (4) and immune systems (5, 6), and effects on electrolyte balance via stimulation of adrenal mineralocorticoid release. It seems logical that the necessity of orchestrating these potent effectors to adapt to specific challenges would require sophisticated modes of signalling between the pituitary cells and numerous circulating factors. We have recently described a stressful social interaction that elicits increases in plasma levels of the anterior pituitary peptide hormones derived from proopiomelanocortin (POMC): viz., adrenocorticotropin (ACTH), β-endorphin (β-EP) and β-Mipotrophic hormone (β-LPH) (7). Increases were also seen in plasma levels of the adrenal cortical hormone, Cortisol (CS), as well as prolactin (PRL), an anterior pituitary hormone not derived from POMC.


Atrial Natriuretic Peptide Plasma Renin Activity Corticotropin Release Factor Paraventricular Nucleus Median Eminence 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • J. L. Meyerhoff
    • 1
  • M. A. Oleshansky
    • 1
  • K. T. Kalogeras
    • 1
    • 2
  • E. H. Mougey
    • 1
  • G. P. Chrousos
    • 1
    • 2
  • L. G. Granger
    • 1
    • 2
  1. 1.Neurochemistry & Neuroendocrinology Branch Department of Medical Neurosciences Division of NeuropsychiatryWalter Reed Army Institute of ResearchUSA
  2. 2.Developmental Endocrinology Branch, NICHHDNational Institutes of HealthBethesdaUSA

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