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Exchange of Peptides Between the Circulation and the Nervous System: Role of the Blood-Brain Barrier

  • William A. Banks
  • Abba J. Kastin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 274)

Abstract

Peptides can cross the blood-brain barrier (BBB) bidirectionally, that is, from the central nervous system (CNS) to the blood or from the blood to the CNS. Passage occurs by both saturable and nonsaturable mechanisms that can be modified by factors such as lighting, amino acids, monoamines, aging, and neurotoxins. The role of this regulated exchange may be involved in processes such as analgesia, stress, dementia, and addiction. In this review, we shall emphasize the mechanisms regulating exchange of peptides between the circulation and the CNS and explore some of the implications of this exchange on selected biological functions.

Keywords

Amyotrophic Lateral Sclerosis Lipid Solubility Cereb Blood Flow Entry Rate Arginine Vasotocin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • William A. Banks
    • 1
  • Abba J. Kastin
    • 1
  1. 1.Veterans Administration Medical Center and Tulane University School of MedicineNew OrleansUSA

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