Neuroendocrine Mechanisms in the Thermogenic Responses to Diet, Infection, and Trauma

  • Nancy J. Rothwell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 274)


The term thermogenesis can be applied to any component of heat production including basal metabolic rate, physical activity and the energy costs of growth, but is now considered to represent regulatory or adaptive forms of heat production. Of these, non-shivering thermogenesis (NST), which is activated in response to cold, is perhaps the most extensively studied, but it is now recognized that many other forms of thermogenesis share common effector mechanisms. For example, diet-induced thermogenesis (DIT) is stimulated by hyperphagia or nutritional deficiency such as protein deficient diets, and forms an important component of energy balance regulation particularly in small mammals (1,2). Fever is generated by increases in heat production as well as by suppression of heat loss, and the thermogenic responses to fever share many features with NST (3–5). In addition, other pathological stimuli such as injury, cancer and even psychological stress may result in increased rates of heat production that are not necessarily associated with fever but have an important impact on energy balance (2).


Brown Adipose Tissue Corticotropin Release Factor Sodium Valproate Central Injection Brown Adipose Tissue Activity 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Nancy J. Rothwell
    • 1
  1. 1.University of ManchesterManchesterUK

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