Abstract
It has been known as far back as 1936 from the pioneering work of Selye (1) that noxious stimuli of one type or another, activate the release of ACTH which in turn releases adrenal cortical steroids. These then bring about a series of reactions in the body which consist of thymic involution, decrease in size of lymph nodes, lymphopenia, and eosinopenia (1). The role of the nervous system in these phenomena was not established at that time; however, in the early ’50s it became apparent that hypothalamic lesions, particularly in the median eminence of the tuber cinereum would abolish the release of ACTH and adrenal steroids resulting from stress (2). Conversely, stimulation of the hypothalamus could evoke release of ACTH followed by release of adrenal steroids (3).
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McCann, S.M., Rettori, V., Milenkovic, L., Jurčovičová, J., González, M.C. (1990). Role of Monokines in Control of Anterior Pituitary Hormone Release. In: Porter, J.C., Ježová, D. (eds) Circulating Regulatory Factors and Neuroendocrine Function. Advances in Experimental Medicine and Biology, vol 274. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5799-5_20
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