Inhibin and Related Proteins: Localization, Regulation, and Effects

  • F. H. de Jong
  • A. J. Grootenhuis
  • I. A. Klaij
  • W. M. O. Van Beurden
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 274)


The anterior lobe of the pituitary gland secretes two gonadotropic hormones, lutropin (luteinizing hormone, LH) and follitropin (follicle-stimulating hormone, FSH) (1), which stimulate specific cells of the testis and ovary. The biosynthesis and secretion of these hormones is influenced by a number of stimulating and inhibiting factors. The hypothalamic gonadotropin-releasing hormone (GnRH) stimulates the secretion of both LH and FSH (2), whereas steroid hormones suppress peripheral concentrations of gonadotropins by inhibition of GnRH release into the hypothalamic-hypophysial portal circulation (3) and by direct effects on the pituitary gonadotrophs (4,5).


Granulosa Cell Sertoli Cell Follicular Fluid Follicle Stimulate Hormone Level Ovarian Follicular Fluid 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • F. H. de Jong
    • 1
  • A. J. Grootenhuis
    • 1
  • I. A. Klaij
    • 1
  • W. M. O. Van Beurden
    • 1
  1. 1.Department of Biochemistry, Division of Chemical EndocrinologyErasmus University RotterdamThe Netherlands

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