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Central Action of Adrenal Steroids During Stress and Adaptation

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 274)

Abstract

Adrenal glucocorticoid hormones have a potent influence on disparate aspects of brain function. These steroids control cir.cadian and stress-induced aspects of neuroendocrine regulation, affect different aspects of adaptive behavior, and modulate the activity of the neurotransmitter circuitry underlying these processes. During the past twenty years, extensive research has been conducted to elucidate the mechanism of glucocorticoid action in the brain. Great progress was accomplished when it was discovered that adrenal steroids interact with two receptor systems, mineralocorticoid and glucocorticoid receptors, that display different affinities, capacities, specificities, and neuroanatomical localizations in the central nervous system (1–4).

Keywords

Glucocorticoid Receptor Mineralocorticoid Receptor Receptor Concentration Corticosteroid Receptor Cell Field 
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References

  1. 1.
    Reul, J.M.H.M., and E.R. de Kloet, Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation, Endocrinology 117: 2505–2511, 1985.PubMedCrossRefGoogle Scholar
  2. 2.
    McEwen, B.S., E.R. de Kloet, and W. Rostene, Adrenal steroid receptors and actions in the nervous system, Physiol Rev 66 1121–1188,1986.PubMedGoogle Scholar
  3. 3.
    de Kloet, E.R., and J.M.H.M. Reul, Feedback action and tonic influence of corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems, Psychoneuroendocrinology 12: 83–105, 1987.PubMedCrossRefGoogle Scholar
  4. 4.
    Funder J.W., and K. Sheppard, Adrenocortico steroids and the brain, Ann Rev Physiol 49: 397–411,1987.CrossRefGoogle Scholar
  5. 5.
    McEwen, B.S., J.M. Weiss, and L.S. Schwartz, Selective retention of corticosterone by limbic structures in rat brain, Nature 220: 911–912,1968.PubMedCrossRefGoogle Scholar
  6. 6.
    McEwen, B.S., E.R. de Kloet, and G. Wallach, Interaction in vivo and in vitro of corticoids and progesterone with cell nuclei and soluble macromolecules from rat brain region and pituitary, Brain Res 105: 129–136, 1976.PubMedCrossRefGoogle Scholar
  7. 7.
    Gerlach, J.L., and B.S. McEwen, Rat brain binds adrenal steroid hormone: autoradioautography of hippocampus with corticosterone, Science 175: 1133–1136, 1972.PubMedCrossRefGoogle Scholar
  8. 8.
    Stumpf, W.E., and W. Sar, Anatomical distribution of corticosterone concentrating neurons in rat brain, In W.E. Stumpf and LA. Grant (eds) Anatomical Neuroendocrinology ,Karger, Basel, pp. 254–261,1975.Google Scholar
  9. 9.
    McEwen, B.S., B.S. Stephenson, and L.C. Krey, Radioimmunoassay of brain tissue and cell nuclear corticosterone, J Neurosci Meth 3: 57–65, 1980.CrossRefGoogle Scholar
  10. 10.
    Ermisch, A., and H.J. Rühle, Autoradiographic demonstration of aldosterone-concentrating neuron populations in rat brain, Brain Res 147: 154–158, 1978.PubMedCrossRefGoogle Scholar
  11. 11.
    Veldhuis, H.D., C. van Koppen, M. van Ittersum, and E.R. de Kloet, Specificity of the adrenal steroid receptor system in rat hippocampus, Endocrinology 110: 2044–2051, 1982.PubMedCrossRefGoogle Scholar
  12. 12.
    Wrånge, O., and Z.-Y. Yu, Mineralocorticoid receptor in rat kidney and hippocampus: characterization and quantitation by isoelectric focusing, Endocrinology 113: 243–250, 1983.PubMedCrossRefGoogle Scholar
  13. 13.
    Coirini, H., E.T. Marusic, A.F. DeNicola, T.C. Rainbow, and B.S. McEwen, Identification of minerocorticoid binding sites in rat brain by competition studies and density gradient centrifugation, Neuroendocrinology 37: 354–360, 1983.PubMedCrossRefGoogle Scholar
  14. 14.
    Krozowski, Z.S., and J.W. Funder, Renal minerocorticoid receptors and hippocampal corticosterone binding species have identical intrinsic steroid specificity, Proc Natl Acad Sci USA 80: 6056–6060;, 1983.PubMedCrossRefGoogle Scholar
  15. 15.
    Arriza, J.L., C. Weinberger, G. Cerelli, T.M. Glaser, B.L. Handelin, D.E. Housman, and R.M. Evans, Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor, Science 237: 268–275, 1987.PubMedCrossRefGoogle Scholar
  16. 16.
    de Kloet, E.R., G. Wallach, and B.S. McEwen, Differences in corticosterone and dexamethasone binding in rat brain and pituitary, Endocrinology 96: 598–609, 1975.PubMedCrossRefGoogle Scholar
  17. 17.
    Rees, H.D., W.E. Stumpf, and M. Sar, Autoradiographic studies with [3H]-dexamethasone in the rat brain and pituitary, In W.E. Stumpf and L.D. Grant (eds) Anatomical Neuroendocrinology ,Karger, Basel, pp. 262–269, 1975.Google Scholar
  18. 18.
    Moguilewsky, M., and J.P. Raynaud, Evidence for a specific mineralocorticoid receptor in rat pituitary and brain, J Ster Biochem 12: 309–314, 1980.CrossRefGoogle Scholar
  19. 19.
    Philibert, D., and M. Moguilevsky, RU 28362, a useful tool for the characterization of glucocorticoid and mineralocorticoid receptors, Proceeding of the 65thAnnual Meeting of The Endocrine Society USA ,San Antonio, Texas, pp. 335, Abstract 1018, 1983.Google Scholar
  20. 20.
    Sarrieau, A., M. Vial, D. Philibert, and W. Rostene, In vitro autoradiographic localization of [3H]-corticosterone binding sites in rat hippocampus, Eur J Pharmacol 98: 151–152, 1984.PubMedCrossRefGoogle Scholar
  21. 21.
    Reul, J.M.H.M., and E.R. de Kloet, Anatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis, J Ster Biochem 24: 269–272, 1986.CrossRefGoogle Scholar
  22. 22.
    Reul, J.M.H.M., F.R. van den Bosch, and E.R. de Kloet, Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implication,J Endocrinol115: 459–467, 1987.PubMedCrossRefGoogle Scholar
  23. 23.
    Fuxe, K., A.C. Wikstrm, S. kret, Z-Y. Yu, L. Granholm, M. Zoli, W. Vale, and J-A Gustafsson, Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel-and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptors, Endocrinology 117: 1803–1812,1985.PubMedCrossRefGoogle Scholar
  24. 24.
    Fuxe, K., A. Häfstrand, L.F. Agnati, Z-Y. Yu, A. Cintra, A-C. Wikstrm, S. kret, E. Cantoni, and J-Gustafsson, Immunocytochemical studies on the localization of glucocorticoid receptor immunoreactive nerve cells in the lower brain stem and spinal cord of the male rat using a monoclonal antibody against rat liver glucocorticoid receptor, Neurosci Lett 60: 1–6, 1985.PubMedCrossRefGoogle Scholar
  25. 25.
    Agnati, L.F., K. Fuxe, Z.-Y. Yu, A. Häfstrand, S. kret, A.C. Wikstrm, M. Goldstein, M. Zoli, W. Vale, and J-A Gustafsson, Morphometrical analysis of the distribution of corticotrophin releasing factor, glucocorticoid receptor and phenylethanolamine-N-methyltransferase immunoreactive structures in the paraventricular hypothalamic nucleus of the rat, Neurosci Lett 54: 147–152, 1985.PubMedCrossRefGoogle Scholar
  26. 26.
    van Eekelen, J.A.M., J.Z. Kiss, H.M. Westphal, and E.R. de Kloet, Immunocytochemical study on the intracellular localization of the type 2 glucocorticoid receptor in rat brain, Brain Res 436:120–128,1987.PubMedCrossRefGoogle Scholar
  27. 27.
    Hoolenberg, S.W., C. Weinberger, E.S. Ong, G. Cerelli, A. Oro, R. Lebo, E.B. Thompson;, M.G. Rosenfeld, and R.M. Evans, Primary structure and expression of a functional human glucocorticoid receptor cDNA, Nature 318: 635–641, 1985.CrossRefGoogle Scholar
  28. 28.
    Meisfeld, R., S. Rusconi, P.J. Godowski, B.A. Maler, S. kret, A-C. Wikstrm, J-Gustafsson, and K.R. Yamamoto, Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA, Cell 46: 389–399, 1985.CrossRefGoogle Scholar
  29. 29.
    Evans, R.M., The steroid and thyroid hormone receptor superfamily, Science 240: 889–895, 1988.PubMedCrossRefGoogle Scholar
  30. 30.
    Reul, J.M.H.M., P.T. Pearce, J.W. Funder, and Z.S. Krozowski, Type-I and type-II corticosteroid receptor gene expression in the rat: effect of adrenalectomy and dexamethasone administration, Mol Endocrinol 3: 1674–1680, 1989.PubMedCrossRefGoogle Scholar
  31. 31.
    Arriza, J.L., R.B. Simerly, L.W. Swanson, and R.M. Evans, The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response, Neuron 1: 887–900, 1988.PubMedCrossRefGoogle Scholar
  32. 32.
    van Eekelen, J.A.M., W. Jiang, E.R. de Kloet, and M.C. Bohn, Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus, J Neurosci Res 21: 88–94, 1988.PubMedCrossRefGoogle Scholar
  33. 33.
    Aronsson, M., K. Fuxe, Y. Dong, L.F. Agnati, S. kret, and J Gustafsson, Localization of glucocorticoid receptor mRNA in the male rat brain by in situ hybridization, Proc Natl Acad Sci USA 85: 9331–9335, 1988.PubMedCrossRefGoogle Scholar
  34. 34.
    Kiss, J.Z., J.A.M. Eekelen, J.M.H.M. Reul, H.M. Westphal, and E.R. de Kloet, Glucocorticoid receptor in magnocellular neurosecretory cells, Endocrinology 122: 444–449, 1988.PubMedCrossRefGoogle Scholar
  35. 35.
    Funder, J.W., P.T. Pearce, R. Smith, and A.I. Smith, Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated, Science 242: 583–585, 1988.PubMedCrossRefGoogle Scholar
  36. 36.
    Edwards, C.R.W., P.M. Stewart, D. Burt, L. Brett, MA. McIntyre, W.S. Sutanto, E.R. de Kloet, and C. Monder, Localization of 110-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor, The Lancet II October 29, 1988, pp. 986–989.CrossRefGoogle Scholar
  37. 37.
    de Kloet, E.R., ThA.M. Voorhuis, J.L.M. Leunissen, and B. Koch, Intracellular CBG-like molecules in the rat pituitary, J Ster Biochem 20: 367–371, 1984.CrossRefGoogle Scholar
  38. 38.
    McEwen, B.S., L.T. Lambdin, T.C. Rainbow, and A.F. de Nicola, Aldosterone effects on salt appetite in adrenalectomized rats, Life Sci 43: 38–43, 1986.Google Scholar
  39. 39.
    Rousseau, G., J.D. Baxter, J.W. Funder, I.S. Edelman, and G.M. Tomkins, Glucocorticoid and mineralocorticoid receptors for aldosterone, J Ster Biochem 3: 219–227, 1972.CrossRefGoogle Scholar
  40. 40.
    Funder, J.W., D. Feldman, and I.S. Edelman, Specific aldosterone binding in rat kidney and parotid, J Ster Biochem 3: 209–218, 1972.CrossRefGoogle Scholar
  41. 41.
    Beaumont, K., and D.D. Fanestil, Characterization of the rat brain aldosterone receptors reveals high affinity for corticosterone, Endocrinology 113: 2043–2051, 1983.PubMedCrossRefGoogle Scholar
  42. 42.
    de Kloet, E.R., D. van den Berg, H. van Dijken, E. van der Peet, W. Sutanto, and W. de Jong, Brain corticosteroid receptors and central cardiovascular control, Proceedings of the Satellite Symposium of the 8th International Congress of Endocrinology ,Serono Symposia Obligations, In Press.Google Scholar
  43. 43.
    Gomez-Sanchez, E.P., Intracerebroventricular infusion of aldosterone induces hypertension in rats, Endocrinology 118: 819–823, 1986.PubMedCrossRefGoogle Scholar
  44. 44.
    van den Berg, D.T.W.M., E.R. de Kloet, H.H. van Dijken, and W. de Jong, Differential central effects of mineralo-and glucocorticoid agonists and antagonists on blood pressure, Endocrinology ,In Press.Google Scholar
  45. 45.
    Sutanto, W., and E.R. de Kloet, Species-specificity of corticosteroid receptors in hamster and rat brains, Endocrinology 121: 1405–1411, 1987.PubMedCrossRefGoogle Scholar
  46. 46.
    Sutanto, W., J.A.M. van Eekelen, J.M.H.M. Reul, and E.R. de Kloet, Species-species topography of corticosteroid receptors types in rat and hamster brain, Neuroendocrinology 47: 398–404, 1988.PubMedCrossRefGoogle Scholar
  47. 47.
    Reul, J.M.H.M., E.R. de Kloet, and J. Rothuizen, Mineralocorticoid and glucocorticoid receptors in dog brain and pituitary, In Preparation.Google Scholar
  48. 48.
    Schindler, W.J., and K.M. Knigge, Adrenal secretion by the Golden hamster, Endocrinology 65: 739–747, 1959.PubMedCrossRefGoogle Scholar
  49. 49.
    Schindler, W.J., and K.M. Knigge, In vitro studies and adrenal steroidogenesis by the Golden hamster, Endocrinology 65: 748–765, 1959.51.PubMedCrossRefGoogle Scholar
  50. 50.
    Whitehouse, B.J., and G.P. Vinson, Specific variation in steroid biosynthetic pathways: the formation of Cortisol in hamster adrenal tissue in vitro, J Ster Biochem 2: 307–312, 1971.CrossRefGoogle Scholar
  51. 51.
    Dunlap, N.E., and W.E. Grizzle, Golden Syrian Hamsters: a new experimental model for adrenal compensatory hypertrophy, Endocrinology 114: 1490–1495, 1984.PubMedCrossRefGoogle Scholar
  52. 52.
    Reul, J.M.H.M., F.R. van den Bosch, and E.R. de Kloet, Differential response of type-I and type-II corticosteroid receptors to changes in plasma steroid levels and circadian rhythmicity, Neuroendocrinology 45: 407–412, 1987.PubMedCrossRefGoogle Scholar
  53. 53.
    Mclntyre, W.R., and H.H. Samuels, Triamcinolone acetonide regulates glucocorticoid receptor levels by decreasing the half-life of the activated nuclear receptor form, J Biol Chem 260: 418–427, 1985.Google Scholar
  54. 54.
    Dong, Y., L. Poellinger, J-Gustafsson, and S. kret, Regulation of glucocorticoid receptor expression: evidence for transcriptional and posttranslational mechanisms, Mol Endocrinol 2: 1256–1264, 1988.PubMedCrossRefGoogle Scholar
  55. 55.
    Sapolsky, R.M., L.C. Krey, and B.S. McEwen, Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response, Proc Natl Acad Sci USA 81: 6174–6177, 1984.PubMedCrossRefGoogle Scholar
  56. 56.
    Sapolsky, R.M., L.C. Krey, and B.S. McEwen, The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis, Endocr Rev 7: 284–301, 1986.PubMedCrossRefGoogle Scholar
  57. 57.
    Aus der Muhlen, KA., and H. Ockenfels, Morphologische Veränderungen im diencephalon und telencephalon: Strungen des regelkreises adenohypophyse-nebennierenrinde, Zeitung der Zellforschung 93: 126–141, 1969.CrossRefGoogle Scholar
  58. 58.
    Sachar, E.J., L. Hellman, H.P. Roffwarg, F.S. Halpern, D.K. Fukushima, and T.F. Gallagher, Disrupted 24-hour patterns of Cortisol secretion in Psychotic depression, Arch Gen Psychiatry 28: 19–24, 1973.PubMedCrossRefGoogle Scholar
  59. 59.
    Von Zerssen, D., Mood and behavioural changes under corticosteroid therapy, In T.M. Itil, G. Laudahn, and W.M. Herrmann (eds) Psychotropic Action of Hormones Spectrum, New York, pp. 195–222, 1976.Google Scholar
  60. 60.
    Carroll, B.J., M. Feinberg, J.F. Greden, J. Tarika, AA. Albala, R.F. Haskett, N.M. James, Z. Kronfol, N. Lohr, M. Steiner, J.P. de Vigne, and E. Young, A specific laboratory test for the diagnosis of melancholia: standardization, validation and clinical utility, Arch Gen Psychiatry 38: 15–22, 1981.PubMedCrossRefGoogle Scholar
  61. 61.
    Carroll B.J., The dexamethasone suppression test for melancholia, Br J Psychiatry 140: 292–304, 1982.PubMedCrossRefGoogle Scholar
  62. 62.
    Reul, J.M.H.M., J.A.D.M. Tonnaer, and E.R. de Kloet, Neurotrophic ACTH analogue promotes plasticity of type-I corticosteroid receptor in brain of senescent male rats, Neurobiol Aging 9: 253–260, 1988.PubMedCrossRefGoogle Scholar
  63. 63.
    de Wied, D., and J. Jolles, Neuropeptides derived from pro-opiocortin: behavioural, psychological, and neurochemical effects, Physiol Rev 62: 976–1059, 1982.PubMedGoogle Scholar
  64. 64.
    de Koning, P., and W.H. Gispen, A rationale for the use of melanocortins neural injury, In D.G. Stein and B.A. Sabel (eds) Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injuries ,Plenum Press, New York, pp. 233–258, 1988.Google Scholar
  65. 65.
    de Kloet, E.R., J.M.H.M. Reul, F.R. van den Bosch, J.A.D.M. Tonnaer, and H. Saito, Ginsengoide RG1 and corticosteroid receptors in rat brain, Endocrinol Jpn 34: 213–220, 1987.PubMedCrossRefGoogle Scholar
  66. 66.
    Mclntyre, D.C., Adrenalectomy: protection from kindled emulsion induced amnesia in rats, Physiol Behav 17: 789–795, 1976.CrossRefGoogle Scholar
  67. 67.
    Veldhuis, H.D., E.R. de Kloet, I. van Zoest, and B. Bohus, Adrenalectomy reduces exploratory activity in the rat: a specific role of corticosterone, Horm Behav 16: 191–198, 1982.PubMedCrossRefGoogle Scholar
  68. 68.
    Jhanwar-Uniyal, M., C.R. Roland, and S.F. Leibowitz, Diurnal rhythm of 2-noradrenergic receptors in the paraventricular nucleus and other brain areas: relation to circulating corticosterone and feeding behavior, Life Sci 38: 473–482, 1986.PubMedCrossRefGoogle Scholar
  69. 69.
    Dana, R.C., and J.L. Martinez, Effect of adrenalectomy on the circadian rhythm of LTP, Brain Res 308: 392–396, 1984.PubMedCrossRefGoogle Scholar
  70. 70.
    Barnes, C.A., B.L. McNaughton, G.V. Goddard, R.M. Douglas, and R. Adamec, Circadian rhythm of synaptic excitability in rat and monkey central nervous system, Science 197: 91–92, 1977.PubMedCrossRefGoogle Scholar
  71. 71.
    Micco DJ., J.S. Meyer, and B.S. McEwen, Effects of corticosterone replacement on the temporal patterning of activity and sleep in adrenalectomized rats, Brain Res 200: 206–212, 1980.PubMedCrossRefGoogle Scholar
  72. 72.
    Bohus, B., and E.R. de Kloet, Adrenal steroids and extinction behaviour: antagonism by progesterone, deoxycorticosterone and dexamethasone of a specific effect of corticosterone, Life Sci 28: 433–440,1981.PubMedCrossRefGoogle Scholar
  73. 73.
    Munck, A., P.M. Guyre, and N.J. Holbrook, Physiological function of glucocorticoids in stress and their relation to pharmacological action, Endocr Rev 5: 25–44, 1984.PubMedCrossRefGoogle Scholar
  74. 74.
    Dallman, M.F., S.F. Akana, C.S. Cascio, D.N. Darlington, L. Jacobson, and N. Levin, Regulation of ACTH secretion: variations on a theme of B, In J.H. Clark (ed) Recent Progress in Hormone Research ,Academic Press, Orlando, Volume 43: 113–173, 1987.Google Scholar
  75. 75.
    Ratka, A., W. Sutanto, M. Bloemers, and E.R. de Kloet, On the role of brain mineralocorticoid (type-I) and glucocorticoid (type-II) receptors in neuroendocrine regulation, Neuroendocrinology 50:117–123,1989.PubMedCrossRefGoogle Scholar

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© Plenum Press, New York 1990

Authors and Affiliations

  1. 1.Rudolf Magnus InstituteUtrechtThe Netherlands
  2. 2.Department of Clinical Sciences of Companion Animals, Faculty of Veterinary MedicineUniversity of UtrechtThe Netherlands

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