Central Action of Adrenal Steroids During Stress and Adaptation

  • J. M. H. M. Reul
  • W. Sutanto
  • J. A. M. van Eekelen
  • J. Rothuizen
  • E. R. de Kloet
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 274)


Adrenal glucocorticoid hormones have a potent influence on disparate aspects of brain function. These steroids control cir.cadian and stress-induced aspects of neuroendocrine regulation, affect different aspects of adaptive behavior, and modulate the activity of the neurotransmitter circuitry underlying these processes. During the past twenty years, extensive research has been conducted to elucidate the mechanism of glucocorticoid action in the brain. Great progress was accomplished when it was discovered that adrenal steroids interact with two receptor systems, mineralocorticoid and glucocorticoid receptors, that display different affinities, capacities, specificities, and neuroanatomical localizations in the central nervous system (1–4).


Glucocorticoid Receptor Mineralocorticoid Receptor Receptor Concentration Corticosteroid Receptor Cell Field 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • J. M. H. M. Reul
    • 1
  • W. Sutanto
    • 1
  • J. A. M. van Eekelen
    • 1
  • J. Rothuizen
    • 1
    • 2
  • E. R. de Kloet
    • 1
  1. 1.Rudolf Magnus InstituteUtrechtThe Netherlands
  2. 2.Department of Clinical Sciences of Companion Animals, Faculty of Veterinary MedicineUniversity of UtrechtThe Netherlands

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