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Peripheral Neurohumoral Factors and Central Control of Homeostasis During Altered Sodium Intake

  • Greti Aguilera
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 274)

Abstract

Altered sodium intake leads to activation of compensatory mechanisms to restore sodium balance and circulatory homeostasis through modulation of renal sodium and water transport, vascular tone and sodium appetite (1). The humoral, neural, and local factors involved and the sites at which regulation occurs are shown in Table 1. In addition, coordinated interaction between peripheral and central regulators is critical to obtain the appropriate level of response in the target tissue. Examples of this type of interaction are a) the modulatory effect of plasma potassium, atrial natriuretic peptide, and somatostatin on the adrenal sensitivity to angiotensin II (AII) (2), b) the regulatory effect of vasopressin on baroreflex sensitivity (3), and c) the modulatory effect of circulating factors such as AII and steroids on the central regulation of sympathetic activity (4,5). Mineralocorticoids from the zona glomerulosa of the adrenal have a major role in the control of sodium and water metabolism through its effects on sodium reabsorption at the distal tubule of the nephron. The main mineralocorticoid in man and other mammalian species is aldosterone. The secretion of aldosterone by the adrenal glomerulosa is controlled by a complex set of regulators which include peripheral and central components. In this discussion I shall focus on the regulation of aldosterone secretion and in particular the manner in which humoral and neural elements are coordinated.

Keywords

Sodium Intake Plasma Aldosterone Atrial Natriuretic Factor Zona Glomerulosa Aldosterone Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Greti Aguilera
    • 1
  1. 1.Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human DevelopmentNational Institute of HealthBethesdaUSA

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