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The Tuberoinfundibular Dopaminergic Neurons of the Brain: Hormonal Regulation

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Circulating Regulatory Factors and Neuroendocrine Function

Abstract

In the last few decades, our concepts of the mechanisms by which certain brain cells are involved in the regulation of other cells, including other brain cells, have undergone major alterations, and it seems likely that additional changes of equal, if not greater, significance will be forthcoming in the not distant future. Such advances, when they occur, will likely follow the development of new methods or improvement of existing techniques for evaluating various cellular functions, including secretory functions.

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References

  1. Davis, G.C., A.C. Williams, S.P. Markey, M.H. Ebert, E.D. Caine, C.M. Reichert, and I.J. Kopin, Parkinsonism secondary to intravenous injection of meperidine analogues, Psychiatry Res 1:249–254,1979.

    Article  PubMed  CAS  Google Scholar 

  2. Bruns, B.S., C.C. Chiuech, S.P. Markey, M.H. Ebert, D.M. Jacobowitz, and I.J. Kopin, A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-l,2,3,6-tetrahydropyridine, Proc Natl Acad Sci USA 80: 4546–4550, 1983.

    Article  Google Scholar 

  3. Langston, J.W., and P. Ballard, Chronic parkinsonism in humans due to a product of meperidine-analog synthesis, Science 219: 979–980, 1983.

    Article  PubMed  CAS  Google Scholar 

  4. Langston, J.W., and PA. Ballard, Jr., Parkinson’s disease in a chemist working with l-methyl-4-phenyl-l,2,5,6-tetrahydropyridine, N Engl J Med 309: 310, 1983.

    PubMed  CAS  Google Scholar 

  5. Langston, J.W., MPTP: insights into the etiology of parkinson’s disease, Eur Neurol 1: 2–10, 1987.

    Article  Google Scholar 

  6. Porter, J.C., D.D. Nansel, G.A. Gudelsky, M.M. Foreman, N.S. Pilotte, C.R. Parker, Jr., G.H. Burrows, G.W. Bates, and J.D. Madden, Neuroendocrine control of gonadotropin secretion, Fed Proc 39: 2896–2901, 1980.

    PubMed  CAS  Google Scholar 

  7. Gonzalez, H.A., and J.C. Porter, Mass and in situ activity of tyrosine hydroxylase in the median eminence: effect of hyperprolactinemia, Endocrinology 122: 2212–2211 ,1988.

    Article  Google Scholar 

  8. Chen, C.L., Y. Amenomori, K.H. Lu, J.L. Voogt, and J. Meites, Serum prolactin levels in rats with pituitary transplants or hypothalamic lesions, Neuroendocrinology 6: 220–227, 1970.

    Article  PubMed  CAS  Google Scholar 

  9. Fuxe, K., Cellular localization of monoamines in the median eminence and infundibular stem of some mammals, Acta Physiol Scand 58: 383–344, 1963.

    Article  PubMed  CAS  Google Scholar 

  10. Fuxe, K., and T. Hökfelt, Further evidence for the existence of tuberoinfundibular dopamine neurons, Acta Physiol Scand 66: 243–244, 1966.

    Article  Google Scholar 

  11. Hökfelt, T., The possible ultrastructural identification of tuberoinfundibular dopamine-containing nerve endings in the median eminence of the rat, Brain Res 5: 121–123, 1967.

    Article  PubMed  Google Scholar 

  12. Ben-Jonathan, N., C. Oliver, H.J. Weiner, R.S. Mical, and J.C. Porter, Dopamine in hypophysial portal plasma of the rat during the estrous cycle and throughout pregnancy, Endocrinology 100: 452–458,1977.

    Article  PubMed  CAS  Google Scholar 

  13. Levitt, L., S. Spector, A. Sjöerdsma, and S. Udenfriend, Elucidation of the rate-limiting step in norepinephrine biosynthesis in the perfused guinea-pig heart, J Pharmacol Exp Ther 148: 1–8, 1965.

    PubMed  CAS  Google Scholar 

  14. Gudelsky, G A., and J.C. Porter, Release of newly synthesized dopamine into the hypophysial portal vasculature of the rat, Endocrinology 104: 583–587, 1979.

    Article  PubMed  CAS  Google Scholar 

  15. Gudelsky, G.A., and J.C. Porter, Morphine-and opioid peptide-induced inhibition of the release of dopamine from tuberoinfundibular neurons, Life Sci 25: 1697–1702, 1979.

    Article  PubMed  CAS  Google Scholar 

  16. Haskins, J.T., G.A. Gudelsky, R.L. Moss, and J.C. Porter, Iontophoresis of morphine into the arcuate nucleus: effects on dopamine concentrations in hypophysial portal plasma and serum prolactin concentrations, Endocrinology 108: 767–771, 1981.

    Article  PubMed  CAS  Google Scholar 

  17. Reymond, M.J., C. Kaur, and J.C. Porter, An inhibitory role for morphine on the release of dopamine into hypophysial portal blood and on the synthesis of dopamine in tuberoinfundibular neurons, Brain Res 262: 253–258, 1983.

    Article  PubMed  CAS  Google Scholar 

  18. Reymond, MJ., and J.C. Porter, Hypothalamic secretion of dopamine after inhibition of aromatic L-amino acid decarboxylase activity, Endocrinology 111: 1051–1056, 1982.

    Article  PubMed  CAS  Google Scholar 

  19. Pilotte, N.S., and J.C. Porter, Dopamine in hypophysial portal plasma and prolactin in systemic plasma of rats treated with 5-hydroxytryptamine, Endocrinology 108: 2137–2141, 1981.

    Article  PubMed  CAS  Google Scholar 

  20. Okuno, S., and H. Fujisawa, A new mechanism for regulation of tyrosine 3-monooxygenase by end product and cyclic AMP-dependent protein kinase, J Biol Chem 260: 2633–2635, 1985.

    PubMed  CAS  Google Scholar 

  21. Gudelsky, G.A., D.D. Nansel, and J.C. Porter, Dopaminergic control of prolactin secretion in the aging male rat, Brain Res 204: 446–450, 1981.

    Article  PubMed  CAS  Google Scholar 

  22. Reymond, M.J., and J.C. Porter, Secretion of hypothalamic dopamine into pituitary stalk blood of aged female rats, Brain Res Bull 1 69–73, 1981.

    Article  Google Scholar 

  23. Lu, K.H., B.R. Hopper, T.H. Vargo, and S.S.C. Yen, Chronological changes in sex steroid, gonadotropin and prolactin secretion in aging female rats displaying different reproductive states, BiolReprod 21:193–203, 1979.

    CAS  Google Scholar 

  24. González, H.A., W. Kedzierski, and J.C. Porter, Mass and activity of tyrosine hydroxylase in the tuberoinfundibular dopaminergic neurons of the aged brain: control by prolactin and ovarian hormones, Neuroendocrinology 48: 663–66, 1988.

    Article  PubMed  Google Scholar 

  25. González, HA., W. Kedzierski, N. Aguila-Mansilla, and J.C. Porter, Hormonal control of tyrosine hydroxylase in the median eminence: demonstration of a central role for the pituitary gland, Endocrinology 124: 2122–2127, 1989.

    Article  PubMed  Google Scholar 

  26. Butcher, R.L., N.W. Fugo, and W.E. Collins, Semicircadian rhythm in plasma levels of prolactin during early gestation in the rat, Endocrinology 90: 1125–1127, 1972.

    Article  PubMed  CAS  Google Scholar 

  27. Wang, P.S., and J.C. Porter, Hormonal modulation of the quantity and in situ activity of tyrosine hydroxylase in neuntes of the median eminence, Proc Natl Acad Sci USA 83: 9804–9806, 1986.

    Article  PubMed  CAS  Google Scholar 

  28. Chen, C.L., and J. Meites, Effects of estrogen and progesterone on serum and pituitary prolactin levels in ovariectomized rats, Endocrinology 86: 503–505, 1970.

    Article  PubMed  CAS  Google Scholar 

  29. Reymond, M.J., J. Arita, C.A. Dudley, R.L. Moss, and J.C. Porter, Dopaminergic neurons in the mediobasal hypothalamus of old rats: evidence for decreased affinity of tyrosine hydroxylase for substrate and cofactor, Brain Res 304: 215–223, 1984.

    Article  PubMed  CAS  Google Scholar 

  30. Sar, M., Distribution of progestin-concentrating cells in rat brain: colocalization of 3H-ORG.2058, a synthetic progestin, and antibodies to tyrosine hydroxylase in hypothalamus by combined autoradiography and immunocytochemistry, Endocrinology 23: 1110–1118, 1988.

    Article  Google Scholar 

  31. Fox, S.R., B.D. Shivers, R.E. Harlan, and D.W. Pfaff, Progesterone receptors in the female rat are localized within dopaminergic neurons of the hypothalamic arcuate nucleus, but not within pituitary lactotrophs, 68th Annual Meeting of the Endocrine Society, (Abstract #434), p. 139, 1986.

    Google Scholar 

  32. Sar, M., Estradiol is concentrated in tyrosine hydroxylase containing neurons of the hypothalamus, Science 223: 938–940, 1984.

    Article  PubMed  CAS  Google Scholar 

  33. MacLusky, N J., and B.S. McEwen, Oestrogen modulates progestin receptor concentrations in some brain regions but not in others, Nature 274: 276–278, 1978.

    Article  PubMed  CAS  Google Scholar 

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© 1990 Plenum Press, New York

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Porter, J.C., Kedzierski, W., Aguila-Mansilla, N., Jorquera, B.A., González, H.A. (1990). The Tuberoinfundibular Dopaminergic Neurons of the Brain: Hormonal Regulation. In: Porter, J.C., Ježová, D. (eds) Circulating Regulatory Factors and Neuroendocrine Function. Advances in Experimental Medicine and Biology, vol 274. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5799-5_1

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  • DOI: https://doi.org/10.1007/978-1-4684-5799-5_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5801-5

  • Online ISBN: 978-1-4684-5799-5

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