Kindling 4 pp 113-126 | Cite as

Genetic Contributions to Kindling: An Experimental Approach

  • Craig D. Applegate
  • James L. Burchfiel
  • Paul E. Neumann
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)


The development of kindled seizures has been shown to be influenced by genetic factors. The establishment of kindling-prone and kindling-resistant rat populations through selective breeding, along with the reported variations in kindling rates among inbred strains of mice strongly suggests the contribution of genetics to kindling [2,6,17,18]. The rapid kindling rates of genetically epilepsy prone rats [29] and El mice [13] in comparison with appropriate controls provide additional examples of the influence of genetic factors on kindled seizure development. However, to date, no systematic analysis of these factors has been reported for kindling-induced seizures.


Recombinant Inbred Inbred Mouse Strain Recombinant Inbred Strain Seizure Susceptibility Motor Seizure 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Craig D. Applegate
    • 1
  • James L. Burchfiel
    • 1
  • Paul E. Neumann
    • 2
  1. 1.Comprehensive Epilepsy Program, Department of NeurologyUniversity of Rochester School of Medicine and DentistryRochesterUSA
  2. 2.Department of NeurologyThe Children’s Hospital and Harvard Medical SchoolBostonUSA

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