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Kindling 4 pp 75-92 | Cite as

Alterations of Synaptic Ultrastructure Induced by Hippocampal Kindling

  • Yuri Geinisman
  • Frank Morrell
  • Leyla deToledo-Morrell
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)

Abstract

Kindling, first discovered by the late Graham Goddard1, is widely regarded as a dramatic, reliable and robust form of neural plasticity2–6. One of the most remarkable features of kindling is that it induces a virtually permanent change in brain function. Synaptic responsiveness of the circuit stimulated during kindling undergoes an augmentation which persists, without further reinforcement, for many months5–9. This exceptionally enduring enhancement of synaptic efficacy caused by kindling and the dependence of the process on protein synthesis10,11 and axonal transport12,13 imply an underlying structural modification of the synapse itself.

Keywords

Dentate Gyrus Perforant Path Medial Entorhinal Cortex Mossy Fiber Synapse Synaptic Morphology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Yuri Geinisman
    • 1
  • Frank Morrell
    • 2
  • Leyla deToledo-Morrell
    • 2
    • 3
  1. 1.Department of Cell Biology and AnatomyNorthwestern University Medical SchoolChicagoUSA
  2. 2.Departments of Neurological SciencesRush Medical CollegeChicagoUSA
  3. 3.Departments of PsychologyRush Medical CollegeChicagoUSA

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