Kindling 4 pp 45-59 | Cite as

Seizure Mechanisms in the Piriform Cortex

  • Jeffrey S. Stripling
  • Doris K. Patneau
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)


We are currently involved in a series of studies whose purpose is to compare and contrast the effects of kindling and long-term potentiation (LTP) in the same cortical system, the olfactory cortex. Our findings regarding LTP are presented in detail elsewhere (20,21,22,23). This paper will present some initial observations regarding seizure mechanisms in the olfactory cortex and discuss their implications.


Olfactory Bulb Granule Cell Layer Piriform Cortex Mitral Cell Olfactory Cortex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cain, D. P. Seizure development following repeated electrical stimulation of central olfactory structures. Ann. N. Y. Acad. Sci. 290: 200–216, 1977.PubMedCrossRefGoogle Scholar
  2. 2.
    Freeman, W. J. Relations between unit activity and evoked potentials in prepyriform cortex in cats. J. Neurophysiol. 31: 337–348, 1968.PubMedGoogle Scholar
  3. 3.
    Freeman, W. J. Petit mal seizure spikes in olfactory bulb and cortex caused by runaway inhibition after exhaustion of excitation. Brain Res. Rev. 11: 259–284, 1986.CrossRefGoogle Scholar
  4. 4.
    Gray, C. M., Freeman, W. J., and Skinner, J. E. Induction and maintenance of epileptiform activity in the rabbit olfactory bulb depends on centrifugal input. Exp. Brain Res. 68: 210–212, 1987.PubMedCrossRefGoogle Scholar
  5. 5.
    Haberly, L. B. Neuronal circuitry in olfactory cortex: Anatomy and functional implications. Chem. Senses 10: 219–238, 1985.CrossRefGoogle Scholar
  6. 6.
    Haberly, L. B., and Bower, J. M. Analysis of association fiber system in piriform cortex with intracellular recording and staining techniques. J. Neurophysiol. 51: 90–112, 1984.PubMedGoogle Scholar
  7. 7.
    Hoffman, W. H., and Haberly, L. B. Bursting induces persistent allor-none EPSPs by an NMDA-dependent process in piriform cortex. J. Neurosci. 9: 206–215, 1989.PubMedGoogle Scholar
  8. 8.
    Kairiss, E. W., Racine, R. J., and Smith, G. K. The development of the interictal spike during kindling in the rat. Brain Res. 322: 101–110, 1984.PubMedCrossRefGoogle Scholar
  9. 9.
    Luskin, M. B., and Price, J. L. The topographic organization of associational fibers of the olfactory system in the rat, including centrifugal fibers to the olfactory bulb. J. Comp. Neurol. 216: 264–291, 1983.PubMedCrossRefGoogle Scholar
  10. 10.
    McIntyre, D. C., and Wong, R. K. S. Cellular and synaptic properties of amygdala-kindled pyriform cortex in vitro. J. Neurophysiol. 55: 1295–1307, 1986.PubMedGoogle Scholar
  11. 11.
    Mori, K. Membrane and synaptic properties of identified neurons in the olfactory bulb. Pros. Neurobiol. 29: 275–320, 1987.CrossRefGoogle Scholar
  12. 12.
    Price, J. L. Beyond the primary olfactory cortex: Olfactory-related areas in the neocortex, thalamus, and hypothalamus. Chem. Senses 10: 239–258, 1985.CrossRefGoogle Scholar
  13. 13.
    Racine, R. J., Milgram, N. W., and Hafner, S. Long-term potentiation phenomena in the rat limbic forebrain. Brain Res. 260: 217–231, 1983.PubMedCrossRefGoogle Scholar
  14. 14.
    Racine, R. J., Mosher, M., and Kairiss, E. W. The role of the pyriform cortex in the generation of interictal spikes in the kindled preparation. Brain Res. 454: 251–263, 1988.PubMedCrossRefGoogle Scholar
  15. 15.
    Racine, R. J., Paxinos, G., Mosher, J. M., and Kairiss, E. W. The effects of various lesions and knife-cuts on septal and amygdala kindling in the rat. Brain Res. 454: 264–274, 1988.PubMedCrossRefGoogle Scholar
  16. 16.
    Rall, W., and Shepherd, G. M. Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. J. Neurophysiol. 31: 884–915, 1968.PubMedGoogle Scholar
  17. 17.
    Rodriguez, R., and Haberly, L. B. Analysis of synaptic events in the opossum piriform cortex with improved current source-density techniques. J. Neurophysiol. 61: 702–718, 1989.PubMedGoogle Scholar
  18. 18.
    Russell, R. D., and Stripling, J. S. Effect of olfactory bulb kindling on evoked potentials in the pyriform cortex. Brain Res. 361: 61–69, 1985.PubMedCrossRefGoogle Scholar
  19. 19.
    Stripling, J. S., Gramlich, C. A., and Cunningham, M. G. Effect of cocaine and lidocaine on the development of kindled seizures. Pharmacol. Biochem. Behay. 32: 463–468, 1989.CrossRefGoogle Scholar
  20. 20.
    Stripling, J. S., and Patneau, D. K. Selective long-term potentiation in the pyriform cortex: Role of the lateral olfactory tract. Soc. Neurosci. Abstr. 12: 508, 1986.Google Scholar
  21. 21.
    Stripling, J. S., and Patneau, D. K. Role of association fibers in selective long-term potentiation in the pyriform cortex. Soc. Neurosci. Abstr. 14: 1189, 1988.Google Scholar
  22. 22.
    Stripling, J. S., Patneau, D. K., and Gramlich, C. A. Selective longterm potentiation in the pyriform cortex. Brain Res. 441: 281–291, 1988.PubMedCrossRefGoogle Scholar
  23. 23.
    Stripling, J. S., Patneau, D. K., and Gramlich, C. A. Selective longterm potentiation in the piriform cortex: Characterization and anatomical distribution. In preparation.Google Scholar
  24. 24.
    Stripling, J. S., and Russell, R. D. Twenty-four-hour post-seizure inhibition during limbic kindling requires seizure generalization. Neurosci. Let. 99: 208–213, 1989.CrossRefGoogle Scholar
  25. 25.
    Tseng, G.-F., and Haberly, L. B. Paired shocks induce a very high amplitude facilitation of late EPSPs in deep neurons in piriform cortex. Soc. Neurosci. Abstr. 13: 156, 1987.Google Scholar
  26. 26.
    Tseng, G.-F., and Haberly, L. B. Characterization of synaptically mediated fast and slow inhibitory processes in piriform cortex in an in vitro slice preparation. J. Neurophysiol. 59: 1352–1376, 1988.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Jeffrey S. Stripling
    • 1
  • Doris K. Patneau
    • 1
  1. 1.Department of PsychologyUniversity of ArkansasFayettevilleUSA

Personalised recommendations