Metabolic Maps of Kindling: A Sequential Double-Label Deoxyglucose Study
Ever since the first description of the kindling phenomenon(6), it has been widely believed that kindling can induce disseminated and long-lasting functional changes in the brain. This is evidenced, for example, by the evolution of new seizure manifestations implicating different functional categories along with the development of kindling, and by the transfer phenomenon at various brain sites directly or indirectly innervated from the focus. Such disseminated functional alterations must relate not only to the seizure phenomenon but also to the secondary brain dysfunction manifested in some epileptics. However, we do not yet have a comprehensive knowledge of the anatomical system of kindling and induced alterations.
KeywordsCortical Stimulation Tracer Image Quantification Talk Label Tracer Seizure Response
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- (1).Ackermann, R.F., Chugani, H.T., Handforth, A., Moshe, S.L., CaldecottHazard, S., and Engel,J.,Jr., 1986, Autoradiographic studies of cerebral metabolism and blood flow in rat amygdala kindling, in:Kindling 3, J.A. Wada, ed., Raven Press, New York.Google Scholar
- Friedman, H.R., Bruce, C.J., and Goldman-Rakic, P.S., 1984, Double-label 2-DG technique yields double dissociation of functional states with an image differencing method, Soc. Neurosci. Abstr., 1002.Google Scholar
- (6).Goddard,G.V., McIntyre, D.C., and Leech, C.K., 1969, A permanent change in brain function resulting from daily electrical stimulation, Exp. Neurol., 25: 295–330.Google Scholar
- (8).Krieg, W.J.S., 1946, Connections of the cerebral cortex. I.The albino rat. A. Topography of the cortical areas, J. Comp. Neurol., 84: 221–275.Google Scholar
- (12).no, K., Mori, K., Baba, H., Seki, K., and Wada, J.A., 1986, A new chronic model of partial onset generalized seizure induced by low frequency cortical stimulation: Its relationship to the kindling phenomenon, in: Kindling 3, J.A. Wada, ed., Raven Press, New York.Google Scholar
- (16).Sokoloff, L., Reivich, M., Kennedy, C., Des Rosiers, M.H., Patak, K.D., Pettigrew, K.D., Sakurada, 0., and Shinohara, M., 1977, The [14C] deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized rat, J. Neurochem., 28: 897–916.PubMedCrossRefGoogle Scholar