Kindling 4 pp 33-44 | Cite as

Metabolic Maps of Kindling: A Sequential Double-Label Deoxyglucose Study

  • Kenji Ono
  • Hiroshi Baba
  • Shuhei Nishimura
  • Juhn A. Wada
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)


Ever since the first description of the kindling phenomenon(6), it has been widely believed that kindling can induce disseminated and long-lasting functional changes in the brain. This is evidenced, for example, by the evolution of new seizure manifestations implicating different functional categories along with the development of kindling, and by the transfer phenomenon at various brain sites directly or indirectly innervated from the focus. Such disseminated functional alterations must relate not only to the seizure phenomenon but also to the secondary brain dysfunction manifested in some epileptics. However, we do not yet have a comprehensive knowledge of the anatomical system of kindling and induced alterations.


Cortical Stimulation Tracer Image Quantification Talk Label Tracer Seizure Response 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Kenji Ono
    • 1
  • Hiroshi Baba
    • 2
  • Shuhei Nishimura
    • 3
  • Juhn A. Wada
    • 3
  1. 1.Departments of PhysiologyNagasaki University School of MedicineNagasaki, 852Japan
  2. 2.Departments of NeurosurgeryNagasaki University School of MedicineNagasaki, 852Japan
  3. 3.Divisions of Neurosciences and Neurology, Faculty of MedicineThe University of British ColumbiaVancouverCanada

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