Is the Pyriform Cortex Important for Limbic Kindling?
Interest in the contribution of the pyriform cortex to complex partial seizures is not new. In the 1890s Hughlings Jackson and colleagues (9, 10) described a lesion limited to the human uncus, the homologue of the rodent pyriform cortex (2), which they believed initiated ‘uncinate fits’. The development of elaborate behavioral symptoms during the uncinate seizure was presumed to be a result of seizure spread beyond this area, perhaps to the frontal cortex via the uncinate fasciculus (25). Occasionally these spontaneous uncinate seizures developed secondarily into full generalized convulsions, an outcome frequently observed after electrical stimulation of the uncus (21). Thus, it seems that provocation of the uncus is able to directly trigger, or gain access to mechanisms necessary to trigger, secondarily generalized convulsions.
KeywordsNMDA Receptor Status Epilepticus Generalize Seizure Basolateral Amygdala Uncinate Fasciculus
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