Kindling 4 pp 397-408 | Cite as

Claustrum and Amygdaloid Kindling

  • T. Kudo
  • J. A. Wada
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)


The motor cortex1,2, basal ganglia3,4, substantia nigra3, 5, substantia innominata6,7 all seem to play a respective role in generation of amygdaloid (AM) kindled convulsion. However, mechanism of functional linkage from the AM which is non motor structure to a motor mechanism responsible for the AM kindled convulsion is not known.


Convulsive Seizure Motor Mechanism Onset Partial Seizure Reciprocal Connection Clonic Convulsion 


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  1. 1.
    J. A. Wada, and A. Wake, Dorsal frontal, orbital and mesial frontal cortical lesion and amygdaloid kindling in cats, Can. J. Neurol. Sci. 4: 107 (1977)PubMedGoogle Scholar
  2. 2.
    J. A. Wada, T. Mizoguchi, and S. Komai, Cortical motor activation in amygdaloid kindling: observations in nonepileptic rhesus monkeys with anterior two - thirds callosal bisection,in: “ Kindling 2,” J. A. Wada, ed., Raven Press, New York (1981)Google Scholar
  3. 3.
    J. Engel, L. Wolfson, and L. Brown, Anatomical correlates of electrical and behavioral events related to amygdaloid kindling, Ann. Neurol. 3: 538 (1978)PubMedCrossRefGoogle Scholar
  4. 4.
    M. Uno, and N. Ozawa, Neural mechanism of epileptic automatism in amygdaloid kindling, J. Jpn. Epil. Soc. 5: 122 (1987).CrossRefGoogle Scholar
  5. 5.
    J. O. McNamara, M. T. Galloway, L. C. Rigsbee, and C. Shin, Evidence implicating substantia nigra in regulation of kindled seizure threshold, J. Neurosci. 4: 2410 (1984)PubMedGoogle Scholar
  6. 6.
    K. Morita, M. Okamoto, K. Seki, and J. A. Wada, Suppression of amygdala - kindled seizure in cats by enhanced GABAergic transmission in the substantia innominata, Exp. Neurol. 89: 225 (1985)Google Scholar
  7. 7.
    M. Okamoto, and J. A. Wada, Reversible suppression of amygdaloid kindled convulsion following unilateral gabaculine injection into the substantia innominata, Brain Res. 305: 389 (1984)PubMedCrossRefGoogle Scholar
  8. 8.
    I. Ishikawa, S. Kawamura, and O. Tanaka, An experimental study on the efferent connections of the amygdaloid complex in the cat, Acta Med. Okayama 23: 519 (1969)Google Scholar
  9. 9.
    J. E. Krettek, and J. L. Price, A description of the amygdaloid complex in the rat and cat with observations on intra - amygdaloid axonal connections, J. Comp. Neur. 178: 255 (1978)PubMedCrossRefGoogle Scholar
  10. 10.
    G. Macchi, M. Bentivoglio, D. Minciacchi, and M. Molinari, The organization of the claustroneocortical projections in the cat studied by means of the HRP retrograde axonal transport, J. Comp. Neur. 195: 681 (1981)PubMedCrossRefGoogle Scholar
  11. 11.
    D. L. Andersen, Some striatal connections to the claustrum, Exp. Neurol. 20: 261 (1968)Google Scholar
  12. 12.
    T. Arikuni, and K. Kubota, Claustral and amygdaloid afferents to the head of the caudate nucleus in macaque monkeys, Neurosci. Res. 2: 239 (1985)Google Scholar
  13. 13.
    P. Sloniewski, K. G. Usunoff, and C. Pilgrim, Diencephalic and mesencephalic afferents of the rat claustrum, Anat. EMbryol. 173: 401 (1986)CrossRefGoogle Scholar
  14. 14.
    P. Flindt, Egebak, and R. B. Olsen, Some efferent connections of the feline claustrum, Neurosci. Lett. (Suppl) 1: 159 (1978)Google Scholar
  15. 15.
    F. Hiddema, and J. Droogleever Fortuyn, The projection of the intermediary nuclear system of the thalamus and of the parataenial and paraventricular nucleus in the rat, Psychiat. Neurol. Neurochir. 63: 8 (1960)Google Scholar
  16. 16.
    J. Jimenez-Castellanos, and F. Reinoso-Suarez, Topographical organization of the afferent connections of the principal ventromedial thalamic nucleus in the cat, J. Comp. Neur. 236: 297 (1985)PubMedCrossRefGoogle Scholar
  17. 17.
    J. L. Velayos, and F. Reinoso - Suarez, Prosencephalic afferents to the mediodorsal thalamic nucleus, J. Comp. Neurol. 242: 161 (1985)Google Scholar
  18. 18.
    A. J. Gabor, and T. L. Peele, Alterations of behavior following stimulation of the claustrum, Electroenceph. Clin. Neurophysiol. 17: 513 (1964)Google Scholar
  19. 19.
    J. R. Stevens, I. Phillip, and R. Beaurepaire, r - vinyl - GABA in endopiriform area suppresses kindled amygdala seizures, Epilepsia 29: 404 (1988)PubMedCrossRefGoogle Scholar
  20. 20.
    M. Norita, Demonstration of bilateral claustro–cortical connections in the cat with the method of retrograde axonal transport of horseradish peroxidase, Arch. histol. Jap, 40: 1–10 (1977)Google Scholar
  21. 21.
    H. J. Markowitsch, E. Irele, R. Bang - Olsen, and P. Flindt - Egebak, Claustral efferents to the cat’s limbic cortex studied with retrograde and anterograde tracing techniques, Neurosci. 12: 409 (1984)CrossRefGoogle Scholar
  22. 22.
    M. P. Witter, H. J. Groenewegen, and A. H. H. Lohman, Reciprocal connections of the insular and piriform claustrum with limbic cortex: an anatomical study in the cat, Neurosci. 24: 519 (1983)CrossRefGoogle Scholar
  23. 23.
    P. Room, and H. J. Groenewegen, Connections of the parahippocampal cortex in the cat. II. subcortical afferents, J. Com. Neur. 251: 451 (1986)CrossRefGoogle Scholar
  24. 24.
    J. A. Wada, T. Nakashima, and Y. Kaneko, Forebrain bisection and feline amygdaloid kindling, Epilepsia 23: 521 (1982)PubMedCrossRefGoogle Scholar
  25. 25.
    T. Nakatsu, The effects of bilateral ventral hippocampal lesions on amygdaloid kindling in cats, Okayama Igakkai Zasshi 97: 855 (1985).Google Scholar
  26. 26.
    T. Hiyoshi, and J. A. Wada, Midline thalamic lesion and feline amygdaloid kindling. I. Effect of lesion placement prior to kindling, Electroenceph. Clin. Neurophysiol. 70: 325 (1988)Google Scholar
  27. 27.
    T. Hiyoshi, and J. A. Wada, Midline thalamic lesion and feline amygdaloid kindling. II. Effect of lesion placement upon completion of primary site kindling, Electroenceph. Clin. Neurophysiol. 70: 339 (1988)Google Scholar
  28. 28.
    J. A. Wada, and M. Sato, Generalized convulsive seizures induced by daily electrical stimulation of the amygdala in cats, Neurology 24: 565 (1074)Google Scholar
  29. 29.
    A. Wake, and J. A. Wada, Transfer and interference in amygdaloid kindling in cats, Can. J. Neurol. Sci. 4: 5 (1977)PubMedGoogle Scholar
  30. 30.
    A. L. Berman, and E. G. Jones, “The thalamus and basal telencephalon of the cat. A cytoarchitectonic atlas with stereotaxic coordinates,” The University of Wiscosin Press, Wiscosin (1982)Google Scholar
  31. 31.
    H. Fukuda, J. A. Wada, D. Riche, and R. Naquet, Role of the corpus callosum and hippocampal commissure on transfer phenomenon in amygdala-kindled cats, Exp. Neurol. 98: 189 (1987)Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • T. Kudo
    • 1
  • J. A. Wada
    • 1
  1. 1.Divisions of Neurosciences and NeurologyUniversity of British ColumbiaVancouverCanada

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