Kindling 4 pp 371-381 | Cite as

The Role of the Hippocampal System in the Epileptic Transference Phenomenon of Kindling

  • Motoi Okamoto
  • Ritsuo Nakachi
  • Kiyoshi Morimoto
  • Mitsumoto Sato
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)


Transference phenomenon (transfer) refers to a phenomenon where electrical or chemical kindling at one brain site is accelerated when another brain site has been kindled. Transfer is observed at brain sites which have synaptic connection with the primary kindled site. It has been considered that repeated synaptic bombardment (such as afterdischarge) from the primary focus results in a secondary functional change demonstrated by an accelerated kindling rate. Therefore, the study on the neural mechanism of transfer is important to the understanding of the mechanism of development of secondary epileptogenic focus, as well as to add to the knowledge of the neurophysiological background of memory or neuronal plasticity.


Corpus Callosum Secondary Site Ventral Hippocampus Mammillary Body Brain Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    McIntyre, D. C., and Goddard, G. V., Transfer, interference and spontaneous recovery of convulsions kindled from the rat amygdala, Electroenceph. Clin. Neurophysiol. 35: 533 (1973)CrossRefGoogle Scholar
  2. 2.
    McIntyre, D. C., and Stuckey, G. N., Dorsal hippocampal kindling and transfer in split-brain rats, Exp. Neurol. 87: 86 (1985)Google Scholar
  3. 3.
    Wake,A. and Wada,J.A., Transfer and interference in amygdaloid kindling in cats, Canad. J. Neurol. Sci. 3: 5 (1977)Google Scholar
  4. 4.
    Wada, J. A., Mizuguchi, T., and Osawa, T., Secondarily generalized convulsive seizures induced by daily amygdaloid stimulation in rhesus monkeys, Neurology 28: 1026 (1978)PubMedGoogle Scholar
  5. 5.
    Wada,J.A., and Osawa,T., Spontaneous recurrent seizure state induced by daily electric amygdaloid stimulation in Senegalese baboons (papio papio), Neurology 26: 273 (1976)PubMedGoogle Scholar
  6. 6.
    McCaughran, J. A., Corcoran, M. E. and Wada, J. A., Role of the forebrain commissures in amygdaloid kindling in rats, Epilepsia 19: 19 (1978)PubMedCrossRefGoogle Scholar
  7. 7.
    Mclntyre, D. C., Split-brain rat: transfer and interference of kindled amygdala convulsions, Canad. J.Neurol. Sci. 2: 429 (1975)Google Scholar
  8. 8.
    Wada,J.A. and Sato,M., The generalized convulsive seizure state induced by daily electrical stimulation of the amygdala in split brain cats, Epilepsia 16: 417 (1975)PubMedCrossRefGoogle Scholar
  9. 9.
    Wada, J. A., Nakashima, T,, and Kaneko, Y., Forebrain bisection and feline amygdaloid kindling, Epilepsia 23: 521 (1982)PubMedCrossRefGoogle Scholar
  10. 10.
    Fukuda, H., Wada, J. A., Riche, D., and Naquet, r., Role of the corpus callosum and hippocampal commissure on transfer phenomenon in amygdalakindled cats, Exp. Neurol., 98: 189 (1987)Google Scholar
  11. 11.
    Hiyoshi,T., and Wada,J.A., Midline thalamic lesion and feline amygdaloid kindling: I.Effect of lesion placement prior to kindling, Electroenceph. Clin. Neurophysiol., 70: 325 (1988)Google Scholar
  12. 11.
    Nakatsu,T., The effects of bilateral ventral hippocampal lesions on amygdaloid kindling in cats, Okayama Igakkai Zasshi 97: 855 (1985)Google Scholar
  13. 13.
    Wada,J.A., and Sato, M., Generalized convulsive seizures induced by daily electrical stimulation of the amygdala in cats: correlative electrographic and behavioral features, Neurology 24: 565 (1974)PubMedGoogle Scholar
  14. 14.
    Jasper, H. N., and Ajmone-Marsan, C., A stereotaxic atlas of the diencephalon of the cat, National Research Council of Canada, Ottawa (1954)Google Scholar
  15. 15.
    Morrell,F., Secondary epileptogenic lesions, Epilepsia 1: 538 (1960)PubMedCrossRefGoogle Scholar
  16. 16.
    Hiyoshi,T., and Wada,J.A., Midline thalamic lesion and feline amygdaloid kindling: II. Effect of lesion upon completion of primary site kindling, Electroenceph. Clin. Neurophysiol., 70: 339 (1988)Google Scholar
  17. 17.
    Wada,J.A. and Komai,S., Effect of anterior two-third callosal bisection upon bisymmetrical and bisynchronous generalized convulsions kindled from amygdala in epileptic baboon, papio papio, in“Epilepsy and the Corpus Callosum” A.G.Reeves, ed., Plenum Press, New York (1985)Google Scholar
  18. 18.
    McCaughran, J. A., Corcoran, M. E., and Wada, J. A., Fac i l i tat ion of secondary site amygdaloid kindling following bisection of the corpus callosum and hippocampal commissure in rats, Exp. Neurol. 57: 132 (1977)Google Scholar
  19. 19.
    Wada,J.A., The clinical relevance of kindling: species, brain sites and seizure susceptibility, in:“Limbic Mechanisms”, K.E.Livingston and O.Hornykiewicz, eds., Plenum Press, New York (1978)Google Scholar
  20. 20.
    Morrell,F., Secondary epileptogenesis in man, Arch. Neurol. 42: 318 (1985)PubMedCrossRefGoogle Scholar
  21. 21.
    Papez,J.W., A proposed mechanism of emotion, Arch. Neurol. Psychiat., 38: 725 (1937)Google Scholar
  22. 22.
    Saunders, R.C., Impairment in recognition memory after mammillary body lesions in monkeys, Soc. Neurosci. Abstr., 9: 28 (1983)Google Scholar
  23. 23.
    Zola-Morgan, S., Squire, L. R. and Amaral, D. G., Human amnesia and the mesial temporal region: enduring memory impairment following a bilateral lesion limited to field CAI of the hippocampus, J. Neurosci., 6: 2950 (1986)PubMedGoogle Scholar
  24. 24.
    Goddard, G. V., McIntyre, D.C., and Leech, C. K., A permanent change in brain function resulting from daily electrical stimulation, Exp. Neurol., 25: 295 (1969)Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Motoi Okamoto
    • 1
  • Ritsuo Nakachi
    • 1
  • Kiyoshi Morimoto
    • 1
  • Mitsumoto Sato
    • 2
  1. 1.Department of NeuropsychiatryOkayama University Medical SchoolOkayama, 700Japan
  2. 2.Department of Psychiatry, Faculty of MedicineTohoku UniversityJapan

Personalised recommendations