Kindling 4 pp 357-370 | Cite as

Amygdala Versus Local Anesthetic Kindling: Differential Anatomy, Pharmacology, and Clinical Implications

  • Robert M. Post
  • Susan R. B. Weiss
  • Mike Clark
  • Takashi Nakajima
  • Agu Pert
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)

Abstract

Electrical kindling, first described by Goddard and associates (14), was elicited by repeated intermittent electrical stimulation of a variety of brain areas culminating in the production of major motor seizures to a previously subconvulsant stimulation. This process is accompanied by growth and spread of afterdischarges and a succession of behavioral seizure stages progressing to the onset of major motor seizures (14,38). With sufficient repetition of the kindled seizures, a stage of spontaneity occurs in which exogenous electrophysiological stimulation is no longer required in order for the animal to experience a seizure (20–22,43).

Keywords

Caffeine Diazepam Lidocaine Epoxide Amphetamine 

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Robert M. Post
    • 1
  • Susan R. B. Weiss
    • 1
  • Mike Clark
    • 1
  • Takashi Nakajima
    • 1
  • Agu Pert
    • 1
  1. 1.Biological Psychiatry BranchNIMHBethesdaUSA

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