Kindling 4 pp 343-355 | Cite as

Pharmacological Dissociation between the Mechanisms of Kindling and Long-Term Potentiation by APV and Urethane Anesthesia

  • Donald P. Cain
  • Francis Boon
  • Eric L. Hargreaves
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)


Kindling and long term potentiation (LTP) are among the most widely studied models of neural plasticity. In many respects they are strikingly similar. In addition to the fact that they both model CNS plasticity, the method of inducing them and the neural responses that result are very similar. For example, both are usually induced by the localized application of brief, high-frequency trains of electrical pulses through implanted electrodes, and both result in a lasting increase in the neural response to a constant stimulus (2,10). In addition, recent research has suggested that the two models may share aspects of a common underlying neural mechanism, and this has led to the suggestion that LTP might constitute the cellular mechanism of kindling (1,7,17).


Long Term Potentiation Stimulation Intensity Guide Cannula Perforant Path Potentiation Effect 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Donald P. Cain
    • 1
  • Francis Boon
    • 1
  • Eric L. Hargreaves
    • 1
  1. 1.Department of PsychologyUniversity of Western OntarioLondonCanada

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