Kindling 4 pp 343-355 | Cite as

Pharmacological Dissociation between the Mechanisms of Kindling and Long-Term Potentiation by APV and Urethane Anesthesia

  • Donald P. Cain
  • Francis Boon
  • Eric L. Hargreaves
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)


Kindling and long term potentiation (LTP) are among the most widely studied models of neural plasticity. In many respects they are strikingly similar. In addition to the fact that they both model CNS plasticity, the method of inducing them and the neural responses that result are very similar. For example, both are usually induced by the localized application of brief, high-frequency trains of electrical pulses through implanted electrodes, and both result in a lasting increase in the neural response to a constant stimulus (2,10). In addition, recent research has suggested that the two models may share aspects of a common underlying neural mechanism, and this has led to the suggestion that LTP might constitute the cellular mechanism of kindling (1,7,17).


Long Term Potentiation Stimulation Intensity Guide Cannula Perforant Path Potentiation Effect 
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  1. 1.
    Baudry, M., 1986, Long-term potentiation and kindling: Similar biochem-ical mechanisms?, in: “Advances in Neurology”, Vol. 44, A.V. Delgado- Escueta et al., ed., Raven Press, New York.Google Scholar
  2. 2.
    Bliss, T.P. and Lomo, T., 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulation of the perforant path. J Physiol, 232: 331.PubMedGoogle Scholar
  3. 3.
    Buzsaki, G., Grastyan, E., Czopf, J., Kellenyi, L. and Prohaska, O., 1981, Changes in neuronal transmission in the rat hippocampus during behavior. Brain Res, 1981, 225: 235.CrossRefGoogle Scholar
  4. 4.
    . Cain, D.P., 1989, Long-term potentiation and kindling: How similar are the mechanisms? Trends Neurosci, 12: 6.PubMedCrossRefGoogle Scholar
  5. 5.
    . Cain, D.P., Desborough, K.A. and McKitrick, D.J., 1988, Retardation of amygdala kindling by antagonism of NMD-aspartate and muscarinic cholinergic receptors: Evidence for the summation of excitatory mechanisms in kindling. Exper Neurol, 100: 179.CrossRefGoogle Scholar
  6. 6.
    . Cain, D.P., Raithby, A. and Corcoran, M.E., 1989, Urethane anesthesia blocks the development and expression of kindled seizures. Life Sci, 44: 1201.PubMedCrossRefGoogle Scholar
  7. 7.
    . Collingridge, G.L. and Bliss, T.P., 1987, NMDA receptors - Their role in long-term potentiation. Trends Neurosci, 10: 288.CrossRefGoogle Scholar
  8. 8.
    . de Jong, M. and Racine, R.J., 1985, The effects of repeated induction of long-term potentiation in the dentate gyrus. Brain Res, 328: 181.CrossRefGoogle Scholar
  9. 9.
    . Gilbert, M., 1988, The NMDA-receptor antagonist, MK-801, suppresses limbic kindling and kindled seizures. Brain Res, 463: 90.PubMedCrossRefGoogle Scholar
  10. 10.
    . Goddard, G.V., McIntyre, D.C. and Leech, C.K., 1969, A permanent change in brain function resulting from daily electrical stimulation. Exper Neurol, 25: 295.CrossRefGoogle Scholar
  11. 11.
    Harris, E.W., Ganong, A.H. and Cotman, C.W., 1984, Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors. Brain Res, 323: 132.PubMedCrossRefGoogle Scholar
  12. 12.
    Maru, E. and Goddard, G., 1987, Alteration in dentate neuronal activities associated with perforant path kindling. III. Enhancement of synaptic inhibition. Exper Neurol, 96: 46.CrossRefGoogle Scholar
  13. 13.
    Morris, R.G.M., Anderson, E., Lynch, G.S. and Baudry, M., 1986, Selective impairment of learning and blockade of long-term potentiation by an Nmethyl-D-aspartate receptor antagonist, AP5. Nature, 319: 774.PubMedCrossRefGoogle Scholar
  14. 14.
    Racine, R.J., 1972, Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol, 32: 281.PubMedCrossRefGoogle Scholar
  15. 15.
    Racine, R.J., Burnham, W.M., Gartner, J.G. and Levitan, D., 1973, Rates of motor seizure development in rats subjected to electrical brain stimulation: Strain and interstimulation interval effects. Electroencephalogr Clin Neurophysiol, 35: 553.PubMedCrossRefGoogle Scholar
  16. 16.
    Racine, R.J., Burnham, W.M., Gilbert, M.E. and Kairiss, E.W., 1986, Kindling mechanisms: I. Electrophysiological studies, in: “Kindling 3” J.A. Wada, ed., Raven Press, New York.Google Scholar
  17. 17.
    Slater, N.T., Stelzer, A. and Galvan, M., 1985, Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hippo-campus. Neurosci Lett, 60: 25.PubMedCrossRefGoogle Scholar
  18. 18.
    Sutula, T. and Steward, 0., 1987, Facilitation of kindling by prior induction of long-term potentiation in the perforant path. Brain Res, 420: 109.PubMedCrossRefGoogle Scholar
  19. 19.
    Tuff, L.P., Racine, R.J. and Adamec, R., 1983, The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression. Brain Res, 277: 79.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Donald P. Cain
    • 1
  • Francis Boon
    • 1
  • Eric L. Hargreaves
    • 1
  1. 1.Department of PsychologyUniversity of Western OntarioLondonCanada

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