Pharmacological Dissociation between the Mechanisms of Kindling and Long-Term Potentiation by APV and Urethane Anesthesia
Kindling and long term potentiation (LTP) are among the most widely studied models of neural plasticity. In many respects they are strikingly similar. In addition to the fact that they both model CNS plasticity, the method of inducing them and the neural responses that result are very similar. For example, both are usually induced by the localized application of brief, high-frequency trains of electrical pulses through implanted electrodes, and both result in a lasting increase in the neural response to a constant stimulus (2,10). In addition, recent research has suggested that the two models may share aspects of a common underlying neural mechanism, and this has led to the suggestion that LTP might constitute the cellular mechanism of kindling (1,7,17).
KeywordsLong Term Potentiation Stimulation Intensity Guide Cannula Perforant Path Potentiation Effect
Unable to display preview. Download preview PDF.
- 1.Baudry, M., 1986, Long-term potentiation and kindling: Similar biochem-ical mechanisms?, in: “Advances in Neurology”, Vol. 44, A.V. Delgado- Escueta et al., ed., Raven Press, New York.Google Scholar
- 16.Racine, R.J., Burnham, W.M., Gilbert, M.E. and Kairiss, E.W., 1986, Kindling mechanisms: I. Electrophysiological studies, in: “Kindling 3” J.A. Wada, ed., Raven Press, New York.Google Scholar