Basic Mechanisms Underlying Seizure-Prone and Seizure-Resistant Sleep and Awakening States in Feline Kindled and Penicillin Epilepsy
Epilepsy is a chronic neurological disorder which is manifested at some times and masked at others. Sleep-waking state physiology is one of the most well documented factoKs affecting the clinical expression or suppression of human epilepsy1,2. Specifically, non-rapid-eye-movement (NREM) sleep and the gradual process of awakening from NREM sleep are the most vulnerable periods for seizures, especially convulsions. Moreover, the type of epilepsy is an important consideration in the timing of convulsions. Temporal lobe epilepsy with secondary generalized convulsions is the most common pure sleep epilepsy, with convulsions occurring in NREM or the transition from NREM to rapid-eye-movement (REM) sleep in nearly 60% of the patients2. In contrast, over 90% of patients with primary generalizgd, “petit mal” epilepsy display convulsions exclusively after awakening2. Finally, type of epilepsy is not a factor in the suppression of seizures during REM sleep. REM sleep is the most anti-epileptic state in the sleep-wake cycle for all generalized electrographic (EEG) and clinical seizures1.
KeywordsTemporal Lobe Epilepsy NREM Sleep Posterior Hypothalamus Seizure Susceptibility Spontaneous Seizure
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- 1.M.N. Shouse, Seizures and epilepsy during sleep, in: “Principles and Practice of Sleep Medicine,” M.H. Kryger, T. Roth and W.C. Dement, eds., Saunders, Philadelphia, 1989.Google Scholar
- 5.S.L. Moshe, E.F. Sperber and B.J. Albala, Kindling as a model of epilepsy in developing animals, in: “Kindling and Synaptic Plasticity: The legacy of Graham Goddard,” F. Morrell, ed., Dirkhauser, Boston, in press.Google Scholar
- 12.J. M. Siegel, Brainstem mechanisms generating REM sleep, in: “Principles and Practice of Sleep Medicine,” M.H. Kryger, T. Roth and W.C. Dement, eds., Saunders, Philadelphia, 1989.Google Scholar
- 14.M.N. Shouse and M.B. Sterman. Sleep pathology in experimental epilepsy, in: “Sleep and Epilepsy,” M.B. Sterman, M.N. Shouse and P. Passouant, eds., Academic Press, New York, 1982.Google Scholar
- 17.W.R Hess, Diencephalon-Autonomic and Extrapyramidal Functions, “Grune and Stratton, New York, 1954. Consciousness Symposium” J.F. Freshaye, ed., Blackwell, Oxford, 1954.Google Scholar
- 18.R. S. Szymusiak, T. Iriye and D. J. McGinty, Sleep-waking discharge of neurons in the posterior lateral hypothalamic area of cats. Brain Res. Bull. In Press, 1989.Google Scholar
- 20.M.N. Shouse, J.M. Siegel, M.F. Wu, R.S. Szymusiak and A.R. Morrison. Mechanisms of seizure suppression during rapid-eye-movement (REM) sleep in cats. Brain Res., In Press, 1989.Google Scholar
- 22.M. Jouvet and F. Delorme, Locus coeruleus et sommeil paradoxique, C.R. Soc. Biol. 159: 4790 (1988).Google Scholar
- 25.B.E Jones and H. H. Webster. Neurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-Cholinergic cell area in the cat. I. Effect upon the cholinergic innervation of the brain, Brain Res., 458: 285 (1989)Google Scholar