Kindling 4 pp 299-311 | Cite as

Can Kindling-Induced Sleep Pathology be Corrected by Phenobarbital?

  • Toshio Hiyoshi
  • Juhn A. Wada
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)


Kindled seizure susceptibility, as indicated by the incidence of interictal discharge (IID) and the development of kindled convulsion with an ‘all-or-none’ response to threshold stimulation, is known to persist in amygdaloid (AM) kindled cats for more than 12-months without applying stimulation.1 Many antiepileptic drugs such as Phenobarbital (PB), Phenytoin, Carbamazepine, Valproic Acid and Primidone have been shown to exert either a prophylactic effect on kindling or an anticonvulsive effect on established kindled seizure.2–8 However, the question of whether medication with these drugs can reverse the once established kindled seizure susceptibility remains unanswered.


Total Sleep Time Slow Wave Sleep Seizure Susceptibility Sleep Recording Polygraphic Recording 
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  1. 1.
    J. A. Wada, M. Sato, and M. E. Corcoran, Persistent seizure susceptibility and recurrent spontaneous seizures in kindled cats. Epilepsia, 15: 465–478 (1974).PubMedCrossRefGoogle Scholar
  2. 2.
    J. A. Wada, T. Osawa, M. Sato, A. Wake, M. E. Corcoran, and A. S. Troupin, Acute anticonvulsant effects of Diphenylhydantoin, Phenobarbital and Carbamazepine: a combined electro-clinical and serum level study in amygdaloid kindled cats and baboons. Epilepsia, 17: 77–88 (1976).PubMedCrossRefGoogle Scholar
  3. 3.
    J. A. Wada, M. Sato, A. Wake, J. R. Green, and A. S. Troupin, Prophylactic effects of Phenytoin, Phenobarbital, and Carbamazepine examined in kindling cat preparations. Arch. Neurol., 33: 426–434 (1976).PubMedCrossRefGoogle Scholar
  4. 4.
    J. A. Wada, Pharmacological prophylaxis in the kindling model of epilepsy. Arch. Neurol., 34: 389–395 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    J. A. Wada, Kindling, antiepileptic drugs, seizure susceptibility and a warning. In: “Epilepsy updated: causes and treatment,” P. Robb, ed., Miami, Symposia Specialists Inc. (1980).Google Scholar
  6. 6.
    V. Leviel and R. Naquet, A study of Valproic Acid on the kindling effect. Epilepsia 18: 229–233 (1977).PubMedCrossRefGoogle Scholar
  7. 7.
    N. Kakegawa, An experimental study on the modes of appearance and disappearance of suppressive effect of antiepileptic drugs on kindled seizure. Psychiat. Neurol. Jpn., 88: 81–98 (in Japanese) (1986).Google Scholar
  8. 8.
    T. Hiyoshi, S. Suzuki, K. Yagi, and M. Seino, On the anticonvulsive effect of Primidone: an experimental study through overkindling of cat. Jpn. J. Psychiat. Neurol., 40: 505–506 (1986).Google Scholar
  9. 9.
    T. Tanaka, and R. Naquet, Kindling effect and sleep organization in cats. Electroencephalogr. Clin. Neurophysiol., 39: 449–454 (1975).PubMedCrossRefGoogle Scholar
  10. 10.
    G. Rondouin, M. Baldy-Moulinier, and P. Passouant, The influence of hippocampal kindling on sleep organization in cats. Effects of alphamethylparatyrosine. Brain Res., 181: 413–424 (1980).PubMedCrossRefGoogle Scholar
  11. 11.
    M. N. Shouse and M. B. Sterman, Sleep and kindling: II. Effects of generalized seizure induction. Exp. Neurol. 71: 563–580 (1981).PubMedCrossRefGoogle Scholar
  12. 12.
    M. N. Shouse and M. B. Sterman, “Kindling” a sleep disorder: degree of sleep pathology predicts kindled seizure susceptibility in cats. Brain Res., 271: 196–200 (1983).PubMedCrossRefGoogle Scholar
  13. 13.
    H. Cohen, J. Thomas, and W. C. Dement, Sleep stages, REM deprivation and electroconvulsive threshold in the cat. Brain Res., 19: 313–317 (1970).CrossRefGoogle Scholar
  14. 14.
    M. Sato and T. Nakashima, Kindling: Secondary epileptogenesis, sleep and catecholamines. Can. J. Neurol. Sc., 2: 439–446 (1975).Google Scholar
  15. 15.
    R. Kawahara and J. A. Wada, Effect of REM sleep deprivation on amygdaloid kindling in cats. Jpn. J. EEG/EMG., 11: 176–184 (in Japanese) (1983).Google Scholar
  16. 16.
    M. N. Shouse, State disorders and state-dependent seizures in amygdalakindled cats. Exp. Neurol., 92: 601–608 (1986).PubMedCrossRefGoogle Scholar
  17. 17.
    M. N. Shouse and M. B. Sterman, Acute sleep deprivation reduces amygdala-kindled seizure threshold in cats. Exp. Neurol., 78: 716–727 (1982).CrossRefGoogle Scholar
  18. 18.
    R. Kawahara, I. Okubo, T. Tanaka, H. Takeshita, and T. Inomaru, The effect of three anticonvulsants on REM sleep and generalized seizure in amygdaloid-kindled cats. Jpn. J. EEG/EMG., 15: 273–281 (in Japanese) (1987).Google Scholar
  19. 19.
    H. B. Cohen, R. F. II. Duncan, and W. C. Dement, The effect of diphenylhydantoin on sleep in the cat. Electroencephalogr. Clin. Neurophysiol., 24: 401–408 (1968).PubMedCrossRefGoogle Scholar
  20. 20.
    T. Hiyoshi, N. Mori, and J. A. Wada, Feline amygdaloid kindling and sleep. Electroencephalogr. Clin. Neurophysiol., 73: 254–259 (1989).PubMedCrossRefGoogle Scholar
  21. 21.
    T. Hiyoshi and J. A. Wada, Feline amygdaloid kindling and sleep-waking pattern: observation on daily 22-hour polygraphic recording. Epilepsia, (in press).Google Scholar
  22. 22.
    T. Hiyoshi and J. A. Wada, Nine-month phenobarbital administration failed to reverse amygdaloid kindled seizure susceptibility in cats (submitted).Google Scholar
  23. 23.
    R. Ursin and M. B. Sterman, “A manual for recording and scoring of sleep and waking stages in the adult cat.” Brain Information Service/Brain Research Institute, University of California, Los Angeles (1981).Google Scholar
  24. 24.
    J. A. Wada and M. Sato, Generalized convulsive seizures induced by daily electrical stimulation of the amygdala in cats. Neurology, 24: 565–574 (1974).PubMedGoogle Scholar
  25. 25.
    T. Hiyoshi and J. A. Wada, Midline thalamic lesion and feline amygdaloid kindling. I. Effect of lesion placement prior to kindling. Electroencephalogr. Clin. Neurophysiol., 70: 325–338 (1988).PubMedCrossRefGoogle Scholar
  26. 26.
    M. B. Sterman, T. Knauss, D. Lehmann, and C. D. Clemente, Circadian sleep and waking patterns in the laboratory cat. Electroencephalogr. Clin. Neurophysiol., 19: 509–517 (1965).PubMedCrossRefGoogle Scholar
  27. 27.
    R. Ursin, The two stages of slow wave sleep in the cat and their relation to REM sleep. Brain Res., 11: 347–356 (1968).PubMedCrossRefGoogle Scholar
  28. 28.
    R. Ursin, The effects of 5-hydroxytryptophan and L-tryptophan on wakefulness and sleep patterns in the cat. Brain Res., 106: 105–115 (1976).PubMedCrossRefGoogle Scholar
  29. 29.
    E. A. Lucas and M. B. Sterman, The polycyclic sleep-wake cycle in the cat: Effects produced by sensorimotor rhythm conditioning. Exp. Neurol., 42: 347–368 (1974).PubMedCrossRefGoogle Scholar
  30. 30.
    H. B. Cohen and W. C. Dement, Sleep: suppression of rapid eye movement phase in the cat after electroconvulsive shock. Science, 154: 396–398 (1966).PubMedCrossRefGoogle Scholar
  31. 31.
    W. Dement, The effect of dream deprivation. Science, 131: 1705–1707 (1960).PubMedCrossRefGoogle Scholar
  32. 32.
    W. Dement, P. Henry, H. Cohen and J. Ferguson, Studies on the effect of REM deprivation in humans and in animals. Res. Publ. Ass. Nerv. Ment. Dis., 45: 456–468 (1967).Google Scholar
  33. 33.
    W. C. Stern and P. J. Morgane, Theoretical view of REM sleep function: Maintenance of catecholamine systems in the central nervous system. Behavioral Biology, 11: 1–32 (1974).PubMedCrossRefGoogle Scholar
  34. 34.
    I. Oswald and R. G. Priest, Five weeks to escape the sleeping-pill habit. Brit. Med. J., 2: 1093–1095 (1965).PubMedCrossRefGoogle Scholar
  35. 35.
    E. Hartmann, The effect of four drugs on sleep patterns in man. Psychopharmacologia (Berl.), 12: 346–353 (1968).CrossRefGoogle Scholar
  36. 36.
    D. J. Hinman and M. Okamoto, Sleep patterns in cats during chronic low-dose barbiturate treatment and withdrawal. Sleep, 7: 69–76 (1984).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Toshio Hiyoshi
    • 1
  • Juhn A. Wada
    • 2
  1. 1.National Epilepsy CenterShizuoka Higashi HospitalShizuoka 420Japan
  2. 2.Neuroscience and NeurologyUniversity of British ColumbiaVancouverCanada

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