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Kindling 4 pp 267-281 | Cite as

Pharmacological and Toxicological Evaluation of Potential Antiepileptic Drugs in the Kindling Model of Epilepsy

  • Larry G. Stark
  • Steven L. Peterson
  • Timothy E. Albertson
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)

Abstract

The history of the pharmacology of antiepileptic drugs is now over 50 years old and much of the pioneering work can be traced to the discovery and development of phenytoin. The history and details of that particular research have recently been summarized and reviewed [7]. The use of pentylenetetrazol to produce chemoshock seizures and the subsequent discovery of trimethadione brought the science of pharmacology into the domain of antiepileptic drug testing in an even more permanent way. Toman, Swinyard, Goodman, Brown, Richards and Everett published a series of papers that further developed and quantified maximal electroshock and pentylenetetrazol models of epilepsy [31,30,29,28,5] that remain key components in the preclinical testing and evaluation of antiepileptic drugs (AEDs). Among this pioneering work one finds constant emphasis on not only refinement of methods useful for detection of antiepileptic drug efficacy, but on estimation of drug selectivity as a very important consideration.

Keywords

Rank Score Anticonvulsant Effect Maximal Electroshock Protective Index Seizure Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Larry G. Stark
    • 1
  • Steven L. Peterson
    • 2
  • Timothy E. Albertson
    • 1
  1. 1.Departments of Pharmacology, School of MedicineUniversity of CaliforniaDavisUSA
  2. 2.Medical Pharmacology/Toxicology, College of MedicineTexas A & M UniversityCollege Sta.USA

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