Kindling and Excitatory Amino Acids
The kindling effect provides an excellent animal model of human epilepsy, which has been defined as a chronic brain disorder characterized by recurrence of seizures due to excessive discharge of cerebral neurons. In clinical respests, a long lasting seizure susceptibility of the brain relates to outcome of epilepsy, while recurrence of seizures, especially epileptic status, results in difficulties in social functioning of the patients with epilepsy. Using kindling model, these two different processes (seizure susceptibility and seizure induction) can be clearly identified by separating the processes of seizure development during kindling sessions and the fully kindled seizures. In addition, it seems noteworthy that the fully kindled convulsive seizure is different from acute convulsions such as pentetrazol- and penicillin-induced convulsions, due to involvement of kindling-induced seizure susceptibility of the brain in induction of seizures.
KeywordsExcitatory Amino Acid Anticonvulsant Action Perforant Path Seizure Susceptibility Motor Seizure
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