Kindling 4 pp 209-225 | Cite as

Does Electrical and Excitatory Amino Acid Kindling Share a Common Neurobiological Mechanism?

  • Norio Mori
  • Juhn A. Wada
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)


There is convincing evidence that excitatory amino acids, particularly glutamate (GLU) and aspartate (ASP), are involved in basic mechanism of epilepsy (for reviews see refs. 1,2,26). Thus, enhanced release, and reduced tissue levels, of excitatory amino acids have been reported in various animal models of epilepsy (9,13,20,24,34,41,44). Reduced levels of both GLU and ASP have also been demonstrated in tissue excised from human epileptic foci (42,43). In addition, excitatory amino acid antagonists have been shown to block epileptic seizures and epileptiform activity in both rodent and primate models of epilepsy (4,5,6,26,34,39,40).


Electrical Stimulation Excitatory Amino Acid Kynurenic Acid Secondary Site Seizure Development 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Norio Mori
    • 1
  • Juhn A. Wada
    • 2
  1. 1.Department of NeuropsychiatryFukushima Medical CollegeJapan
  2. 2.Division of Neurosciences and NeurologyUniversity of B.C.Canada

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