Kindling 4 pp 127-139 | Cite as

The GABA Hypothesis of Kindling

  • W. McIntyre Burnham
  • Georgia A. Cottrell
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)


The GABA hypothesis, as recently revised (6), may be stated as follows:

“The kindling procedure causes a permanent change in some part of the GABA-A inhibitory system. This leads to a chronic tendency toward GABAergic hypofunction, and to all (or part) of the physiological abnormalities which characterize the ‘kindled state’.”


Kainic Acid Gaba System Procaine Hydrochloride Locus Coeruleus Neuron Kindling Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • W. McIntyre Burnham
    • 1
  • Georgia A. Cottrell
    • 1
  1. 1.Department of PharmacologyUniversity of TorontoTorontoUSA

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