Kindling as a Model of Long-Lasting Plasticity: New Perspectives in the Search for Molecular Mechanisms

  • Gildas Le Gal La Salle
Part of the Advances in Behavioral Biology book series (ABBI, volume 37)


Twenty years after its discovery, kindling continues to give rise to an increasing interest as attested by this fourth symposium and the impressive number of papers dealing with this subject in the literature. But, as kindling studies advance, the objectives tend to differ. Although kindling was initially recognized as a suitable model for studying plasticity, it served primarily in epilepsy research. A considerable amount of works were devoted to the analysis of antiepileptic drugs and the study of the neurobiological basis of epileptogenesis. Now, the overall tendency is to reconcile both aspects in again considering kindling as a model of plasticity. A paper on this subject is presented in the book Kindling 3 (27).


Nerve Growth Factor Mossy Fiber Synaptic Remodel Hippocampal Mossy Fiber Sprouted Mossy Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    ADAMEC,R. (1976). Behavioral and epileptic determinants of predatory attack behavior in the cat. In: Kindling, J.A. Wada (Ed).Raven Press, New York, pp 135–154.Google Scholar
  2. 2.
    BAUDRY,M. (1986). Long-term potentiation and kindling: similar biochemical mechanisms? In: Advances in Neurology, 44, pp 401–410.A.V. Delgado-Escueta, A.A.Ward. Jr.; D.M. Woodbury and R.J. Porter (eds) Raven Press. New York.Google Scholar
  3. 3.
    BENOWITZ,L.I. and ROUTTENBERG,A. (1987). A membrane phosphoprotein associated with neural development, axonal regeneration, phospholipid metabolism, and synaptic plasticity. TINS, 10, 527–532.Google Scholar
  4. 4.
    BLISS, T.V.P. and LOMO,T. (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J. Physiol. ( London ), 232, 331–356.PubMedGoogle Scholar
  5. 5.
    BOAST,C.A. and McINTYRE,D. (1977). Bilateral kindled amygdala foci and inhibitory avoidance behavior in rats: a functional. lesion effect. Physiol. Behay., 18, 25–28.CrossRefGoogle Scholar
  6. 6.
    CAIN, D.P. (1989). Long-term potentiation and kindling: how similar are the mechanisms? TINS, 12, 6–10.PubMedGoogle Scholar
  7. 7.
    CAIN,D.P.; CORCORAN,M. and STAINES,W. (1980). Effects of protein synthesis inhibition on kindling in the mouse. Exp. Neurol. 68, 409–416.Google Scholar
  8. 8.
    CURRAN,T. and MORGAN,J.I. (1987). Memories of fos. Bio Essays, 7, 255–258.Google Scholar
  9. 9.
    DRAGUNOW, M. and ROBERTSON,H.A. (1987). Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus. Nature. 329, 441–442.PubMedCrossRefGoogle Scholar
  10. 10.
    DRAGUNOW, M. and ROBERTSON,H.A. and ROBERTSON,G.S. (1988). Amygdala kindling and c-fos protein(s). Exp. Neurol., 102, 261–263.PubMedCrossRefGoogle Scholar
  11. 11.
    FERNANDEZ-GUARDIOLA,A.; JURADO,J.L. and CALVO,J.M. (1981). Repetitive low-intensity electrical stimulation of cat’s nonlimbic brain structures: dorsal raphe nucleus kindling. in: Kindling 2. J.A.t+ada (Ed.) Raven Press, New York, pp 123–135.Google Scholar
  12. 12.
    FUNABASHI,T.; SASAKI,H. and KIMURA,F. (1988). Intraventricular injection of antiserum to nerve growth factor delays the development of amygdaloid kindling. Brain Res. 458, 132–136.PubMedCrossRefGoogle Scholar
  13. 13.
    GEINISMAN,Y.; MORREL,F. and de TOLEDO-MORREL,L. (1988). Remodelling of synaptic architecture during hippocampal ‘kindling’. Proc. Natl. Acad. Sci. USA., 85, 3260–3264.PubMedCrossRefGoogle Scholar
  14. 14.
    GODDARD,G.V.; McINTYRE,D.C. and LEECH,C.K. (1969). A permanent change in brain function resulting from daily electrical stimulation. Exp. Neurol. 25, 295–330.PubMedCrossRefGoogle Scholar
  15. 15.
    GOFLET,P.; CASTELLUCCI,V.F.; SCHACHER,S. and KANDEL,E.R. (1986). The long and the short of long-term memory–a molecular framework. Nature, 322, 419–122.CrossRefGoogle Scholar
  16. 16.
    HEIMRICH,B.; CLAUS,H.; SCHWEGLER,H. and HAAS,H.L. (1989). Hippocampal mossy fiber distribution and long-term potentiation in two inbred mouse strains. Brain Res. 490, 404–406.PubMedCrossRefGoogle Scholar
  17. 17.
    HIYOSHI,T.; NORI,N. and WADA,J.A. (1989). Feline amygdaloid kindling and sleep. Electoencephal. Clin. Neurophysiol, in apress.Google Scholar
  18. 18.
    HOMAN,R.W. and GOODMAN,J.H. (1988). Endurance of the kindling effect is independent of the degree of generalization. Brain Res., 447, 404–406.PubMedCrossRefGoogle Scholar
  19. 19.
    JONEC,V. and WASTERLAIN,C.G. (1979). Effect of inhibitors of protein synthesis on the development of kindled seizures. Exp. Neurol. 66, 524–532.PubMedCrossRefGoogle Scholar
  20. 20.
    LE GAL LA SALLE,G. (1982). Amygdaloid organization related to the kindling effect. In: Kyoto Symposia. P.A. Buser; W.A. Cobb and T. Okuma (Eds) Elsevier Biochemical Press. pp 239–248.Google Scholar
  21. 21.
    LE GAL LA SALLE,G. (1988). Long-lasting and sequential increase of cfos oncoprotein expression in kainic acid-induced status epilepticus. Neurosci. Letts., 88, 127–130.Google Scholar
  22. 22.
    LE GAL LA SALLE,G. and LAGOWSKA,J. (1980). Amygdaloid kindling procedure reduces severity of morphine withdrawal syndrome in rats. Brain Res., 184, 239–242.CrossRefGoogle Scholar
  23. 23.
    LIPP,H.P.; SCHWEGLER,H.; HEIMRICH,B. and DRISCOLL,P. (1988). Infrapyramidal mossy fiber and two-way avoidance learning: developmental modification of hippocampal circuitry and adult behavior of rats and mice. J. Neurosci. 8, 1905–1921.PubMedGoogle Scholar
  24. 24.
    McINTYRE,D.C. and MOLINO,A. (1972). Amygdala lesions and CER learning: long-term effect of kindling. Physiol. Behay., 8, 1055–1058.CrossRefGoogle Scholar
  25. 25.
    MESSENHEIMER,J.A.; HARRIS,E.W. and STEWARD,O. (1979). Sprouting fibers gain access to circuitry transsynaptically altered by kindling. Exp. Neurol., 64, 469–481.Google Scholar
  26. 26.
    MORGAN,J.I.; COHEN,D.R.; HEMPSTEAD,J.L. and CURRAN,T. (1987). Mapping patterns of c-fos expression in the central nervous system after seizure. Science, 237, 192–197.PubMedCrossRefGoogle Scholar
  27. 27.
    MORRELL,F. and TOLEDO-MORRELL,L. (1986). Kindling as a model of neuronal plasticity. In: Kindling 3. J.A.Wada (Ed) Raven Press, New York, pp 17–35.Google Scholar
  28. 28.
    MORRELL,F.; TSURU,N.; HOEPPNER,T.J.; MORGAM, D. and ,W.H. (1975). Secondary epileptogenesis in frog forebrain: effect of inhibition of protein synthesis. Canad. J. Neurol. Sci. 2, 407–416.Google Scholar
  29. 29.
    NEVEU,R.L.; FINCH,E.A.; BIRD,E.D. and BENOWITZ,L.I. (1988). Growth-associated protein GAP-43 is expressed selectively in associative regions of the adult human brain. Proc. Natl. Acad. Sci. 85, 3638–3642.CrossRefGoogle Scholar
  30. 30.
    PETERSON,S.L.; ALBERTSON,T.E. and STARK,L.G. (1981). Intertrial intervals and kindled seizures. Exp. Neurol. 71, 144–153.PubMedCrossRefGoogle Scholar
  31. 31.
    PETIT,T.L. and MARKUS,E.J. (1987). The cellular basis of learning and memory:the anatomical sequel to neuronal use. In: Neuroplasticity, learning and memory. Alan R. Liss,Inc. pp 87–124.Google Scholar
  32. 32.
    RACINE,R.J.; BURNHAM,W.M.; GARTNER,J.G. and LEVITAN,D. (1973). Rates of motor seizure development in rats subjected to electrical_ brain stimulation: strain and inter-stimulation interval effects. Electroencephal. Clin. Neurophysiol. 35, 553–556.Google Scholar
  33. 33.
    RACINE, R.J. and KAIRISS,E.W. (1987). Long-term potentiation phenomena: The search for the mechanisms underlying memory storage processes.In: Neuroplasticity, Learning and Memory. Alan R. Liss Inc. pp 173–197.Google Scholar
  34. 34.
    REPRESA,A.; LE GAL LA SALLE,G. and BEN ARI,Y. (1989). Hippocampal plasticity in the kindling model of epilepsy in rats. Neurosci. Letts, 99, 345–350.Google Scholar
  35. 35.
    SAFFEN,D.W.; COLE,A.J.; WORLEY,P.F.; CHRISTY,B.A.; RYDER,K. and BARABAN,J.M. (1988). Convulsant-induced increase in transcription factor messenger RNAs in rat brain. Proc. Natl. Acad. Sci. 85, 7795–7799.PubMedCrossRefGoogle Scholar
  36. 36.
    SUNSHINE,J.; BALAK,K.; RUTISHAUSER,U and JACOBSON,M. (1987). Changes in neural cell adhesion molecule (NCAM) structure during vertebrate neural development. Proc. Natl. Acad. Sci. 84, 5986–5990.PubMedCrossRefGoogle Scholar
  37. 37.
    SUTULA,T.; XIAO-XIAN,H., CAVAZOS,J. and SCOTT,G. (1988). Synaptic reorganization in the hippocampus induced by abnormal functional activity. Science, 239, 1147–1150.PubMedCrossRefGoogle Scholar
  38. 38.
    STEVENS,J.R. and LIVERMORE,A.JR. (1978). Kindling of the mesolimbic dopamine system: animal model of psychosis. Neurology, 28, 36–46.PubMedGoogle Scholar
  39. 39.
    STEWARD,O. and FALK,P.M. (1986). Protein-synthetic machinery at postsynaptic sites during synaptogenesis: A quantitative study of the association between polyribosomes and developing synapses. J. Neurone. 6, 412–423.Google Scholar
  40. 40.
    TANAKA,T and NAQUET,R. (1975). Kindling effect and sleep organization in cats. Electroencephal. Clin. Neurophysiol., 39, 449–154.Google Scholar
  41. 41.
    TAUCK,D.L. and NADLER,J.V. (1985). Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J. Neurone. 5, 1016–1022.Google Scholar
  42. 42.
    TRESS,K.H. and HERBERG,L.J. (1972). Permanent reduction in seizure threshold resulting from repeated electrical stimulation. Exp. Neurol. 37, 347–359.Google Scholar
  43. 43.
    VERMA,I.M. and GRAHAM,W.R. (1987). The fos oncogeno. In: Advances in cancer research. 49, pp 29–52.Google Scholar
  44. 44.
    WADA.J.A. (1978). Kindling as a model of epilepsy. Electroencephalogr.Clin. Neurophysiol., 34. 309–316.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Gildas Le Gal La Salle
    • 1
  1. 1.Laboratoire de Physiologie Nerveuse, Département de Neuropharmacologie MoléculaireCentre National de la Recherche ScientifiqueGif-sur-YvetteFrance

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