Mechanisms of Action on Dietary Fibre on Small Intestinal Absorption and Motility

  • Christine Edwards
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 270)


The physical form in which food is ingested and the physical properties of the intestinal chyme produced may determine the rate of intestinal digestion, absorption and transit. When food is eaten as whole plant material, nutrients may be trapped within the cellular structure of the plant. Processes such as cooking1, grinding2 and chewing3 will act to break down this cellular structure releasing the nutrients and allowing greater access to human enzymes speeding up digestion and absorption. Postprandial glycaemia may also be influenced by interactions between carbohydrate and protein within the plant matrix4


Shear Rate Gastric Emptying Dietary Fibre Luminal Content Soluble Dietary Fibre 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Collings, P., Williams, C., MacDonald, I. Effects of cooking on serum glucose and insulin responses to starch. Br Med J, 282; 1032 (1981)CrossRefGoogle Scholar
  2. 2.
    O’Dea, K., Snow, P., Nestel, P. Rate of starch hydrolysis in vitro as a predictor of metabolic responses to complex carbohydrates in vivo. Am J Clin Nutr 34; 1991 (1981)Google Scholar
  3. 3.
    Read, N.W., Welch, I.McL., Austen, C.J., Barnish, C., Bartlett, C.E., Baxter, A.J., Brown, G., Comptom, M.E., Hume, K.E., Storie, I., Wording, J. Swallowing food without chewing; a simple way to reduce postprandial glycaemia. Br J Nutr 55; 43 (1986)CrossRefGoogle Scholar
  4. 4.
    Jenkins, D.J.A., Thorne, M.J., Wolever, T.M.S., Jenkins, A.L., Rao, A.V., Thompson, L.A. The effect of starch-protein interaction in wheat on the glycaemic response and rate of in vitro digestion. Am J Clin Nutr 45; 946 (1987)Google Scholar
  5. 5.
    Jenkins, D.J.A., Wolever, T.M.S., Leeds, A.R., Gassull, M.A., Haisman, P., Dilawari, J., Goff, D.V., Metz, G.L., Albert, K.G.M.M. Dietary fibres, fibre analogues and glucose tolerance: importance of viscosity. Br Med J 1; 1392 (1978)CrossRefGoogle Scholar
  6. 6.
    Isaksson, G., Asp, N-G., Ihse, I. Effect of dietary fibre on pancreatic enzyme activities of ileostomy evacuates and on excretion of fat and nitrogen in the rat. Scand J Gastro 18; 417 (1983)CrossRefGoogle Scholar
  7. 7.
    Sandberg, A., Andersson, H., Hallgeren, B., Hasselblad, K., Isaksson, B. Experimental model for the in vivo determination of dietary fibre and its effect on the absorption of nutrients in the small intestine Br J Nutr 45; 283 (1981)CrossRefGoogle Scholar
  8. 8.
    Vahouny, G.V. Dietary fibres and intestinal absorption of lipids, in: “Dietary Fiber in Health and Disease”, G.V. Vahouny, D. Kritchevsky, eds., Plenum Press, New York (1982)Google Scholar
  9. 9.
    Holt, S., Heading, R.C., Carter, D.C., Prescott, L.F., Tothill, P. Effect of gell forming fibre on gastric emptying and absorption of glucose and paracetomol Lancet 1; 636 (1979)CrossRefGoogle Scholar
  10. 10.
    Blackburn, N.A., Redfern, J.S., Jarjis, M., Holgate, A.M., Hanning, I., Scarpello, J.H.B., Johnson, I.T., Read, N.W. The mechanism of action of guar gum in improving glucose tolerance in man Clin Sci 66; 329 (1984)Google Scholar
  11. 11.
    Edwards, C.A., Blackburn, N.A., Craigen, L., Davison, P., Tomlin, J. Sugden, K., Johnson, I.T., Read, N.W. Viscosity of food gums determined in vitro related to their hypoglycaemic actions Am J Clin Nutr 46; 72 (1987)Google Scholar
  12. 12.
    Sandhu, K.S., El Samahi, M.M., Mena, I., Dooley, C.P., Valenzuela, J.E. Effect of pectin on gastric emptying and gastroduodenal motility in normal subjects. Gastroenterology 92; 486 (1987)Google Scholar
  13. 13.
    Houghton, L.A., Read, N.W., Heddle, R., Horowitz, M., Collins, P.J., Chatterton, B., Dent, J. The relationship of the motor activity of the antrum, pylorus and duodenum to gastric emptying of a solid/liquid mixed meal Gastroenterology 94; 1285 (1988)Google Scholar
  14. 14.
    Meyer, J.H., Elashoff, Y.G.J., Reedy, T., Dressman, J., Amidon, G. Effects of viscosity and fluid outflow on postcibal gastric emptying of solids Am J Physiol 250; G161 (1986)Google Scholar
  15. 15.
    Johnson, I.T., Gee, J.M. Effect of gel-forming food gums on the intestinal unstirred layer and sugar transport in vitro Gut 22; 398 (1981)CrossRefGoogle Scholar
  16. 16.
    Elsenhans, B., Zenker, D., Caspary, W.F., Blume, R. Guaran effect on rat intestinal absorption. A perfusion study. Gastroenterology 86; 645 (1984)Google Scholar
  17. 17.
    Rainbird , A.L., Low, A.G., Zebrowsky, T. Effect of guar gum on glucose and water absorption from isolated jejunal loops in conscious growing pigs Br J Nutr 52: 4898 (1984)CrossRefGoogle Scholar
  18. 18.
    Taylor, R.H., Wolever, T.M.S., Jenkins, D.J.A., Ghafari, H., Jenkins, M.J.A. Viscosity and glucose diffusion: potential for modification of absorption in the small intestine Gut 21; A452 (1980)Google Scholar
  19. 19.
    Jenkins, D.J.A. Slow release carbohydrate and the treatment of diabetes Proc Nutr Soc 40; 227 (1981)CrossRefGoogle Scholar
  20. 20.
    Macagno, E.C., Christensen, J., Lee, C.I. Modelling the effect of wall movements on absorption in the intestine Am J Physiol 243; G541 (1982)Google Scholar
  21. 21.
    Flourie, B., Vidon, N., Florent, C.H., Bernier, J.H. Effect of pectin on jejunal glucose absorption and unstirred layer thickness in normal man Gut 25; 936 (1984)CrossRefGoogle Scholar
  22. 22.
    Dietschey, J.M., Sallee, V.L., Wilson, F.A. Unstirred water layers and absorption across the intestinal mucosa Gastroenterology 61; 932 (1971)Google Scholar
  23. 23.
    Ebihara, K., Masuhara, R., Kirkyama, S. Major determinants of plasma glucose. Flattening activity of a water soluble dietary fibre. Effect of Konjac mannan on gastric emptying and intraluminal glucose diffusion Nutr Rep Internat 23; 1145 (1981)Google Scholar
  24. 24.
    Lucas, M.L. Estimation of sodium chloride diffusion coefficient in gastric mucins Dig Dis Sci 29; 336 (1984)CrossRefGoogle Scholar
  25. 25.
    Edwards, C.A., Johnson, I.T., Read, N.W. Do viscous polysaccharides slow absorption by inhibiting diffusion or convection? Europ J Clin Nutr 42; 307 (1988)Google Scholar
  26. 26.
    Phillips, D.R. The effect of guar gum in solution on diffusion of cholesterol mixed micelles J Sci Food Agric 37; 548 (1986)CrossRefGoogle Scholar
  27. 27.
    Sandstead, H.H., Munoz, J.M., Jacob, R.A., Klevay, L.M., Reck, S.J., Logan, G.M., Dintzis, F.R., Inglett, G.E., Shuey, W.C. Influence of dietary fibre on trace element balance Am J Clin Nutr 31; S180 (1978)Google Scholar
  28. 28.
    Reinhold, J.G., Faradji, B., Abadi, P., Ismail-Beigi, F. Decreased absorption of calcium, magnesium, zinc and phosphorous by humans due to increased fibre and phosphorus intake as wheat bread J Nutr 106; 493 (1976)Google Scholar
  29. 29.
    Eastwood, M.A., Hamilton, D. Studies on the absorption of bile salts to non-absorbed components in the diet Biochim Biophys Acta 152; 165 (1968)Google Scholar
  30. 30.
    Isaksson, G., Lilja, P., Lunquist, I., Ihse, I. Influence of dietary fibre on exocrine pancreatic function in the rat Digestion 27; 57 (1983)CrossRefGoogle Scholar
  31. 31.
    Ikegamu, S., Tsuchihashi, N., Nagayama, S., Innami, S. Effect of viscous indigestible polysaccharides on pancreatic exocrine and biliary secretion in rats. Nutr Rep Internat 26; 239 (1982)Google Scholar
  32. 32.
    Jenkins, D.J.A., Bloom, S.R., Albuquerque, R.H., Leeds, A.R., Sarson, D.L., Metz, G.L., Albert, K.G.M.M. Pectin and complications after gastric surgery: normalisation of postprandial glucose and endocrine responses Gut 21; 57 (1980)CrossRefGoogle Scholar
  33. 33.
    Morgan, L.M., Goulder, T.J., Tsiolakis, D., Marks, V., Albert, K.R.M.M. The effect of unabsorbable carbohydrate on gut hormones Diabetologia 17; 85 (1979)CrossRefGoogle Scholar
  34. 34.
    Morgan, L.M., Tredger, J.A., Madden, A., Kwasowski, P., Marks, V. The effect of guar gum on carbohydrate fat and protein-stimulated gut hormone secretion. Modification of postprandial gastric inhibitory peptide and gastrin responses Br J Nutr 53; 567 (1985)CrossRefGoogle Scholar
  35. 35.
    Schemann, M., Erhlein, H.J. Postprandial patterns of canine jejunal motility and transit of luminal contents Gastroenterology 90; 991 (1986)Google Scholar
  36. 36.
    Welch, I.McL., Worlding, J. The effect of ileal infusion of lipid on the motility pattern in humans after ingestion of a viscous, non-nutrient meal J Physiol 378 12P (1986)Google Scholar
  37. 37.
    Weems, W.A., Seygal, G.E. Fluid propulsion by cat intestinal segments under conditions requiring hydrostatic work Am J Physiol 240; G147 (1981)Google Scholar
  38. 38.
    Fisher, S., Murray, B.E., Rumsey, R.D.E. Factors affecting the volume expelled from isolated segment of rat small intestine during the peristaltic reflex J Physiol 378 15P (1986)Google Scholar
  39. 39.
    Read, N.W., MacFarlane, A., Kinsman, R., Bates, T., Blackhall, N.W., Farrar, G.B.G., Hall, J.C., Moss, G., Morris, A.P., O’Neill, B., Welch, I. Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and entroglucagon in man. Gastroenterology 86; 274 (1984)Google Scholar
  40. 40.
    Blackburn, N.A., Holgate, A.M., Read, N.W. Does guar gum improve postprandial hyperglycaemia in humans by reducing small intestinal contact area? Br J Nutr 52; 197 (1984)CrossRefGoogle Scholar
  41. 41.
    Brown, N.J., Worlding, J., Rumsey, R.D.E., Read, N.W. The effect of guar gum on the distribution of a radiolabelled meal in the gastrointestinal ltract of the rat Br J Nutr 59; 223 (1988)CrossRefGoogle Scholar
  42. 42.
    O’Connor, N., Tredger, J., Morgan, L. Viscosity differences between various guar gums Diabetologia 20; 612 (1981)Google Scholar
  43. 43.
    Spiller, R.C., Brown, M.L., Phillips, S.F. Emptying of the terminal ileum in intact humans. Influence of meal residue and ileal motility Gastroenterology 92; 724 (1987)Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Christine Edwards
    • 1
  1. 1.Subdepartment of Human Gastrointestinal Physiology and NutritionUniversity of SheffieldSheffieldUK

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