Modulation of ATP Sensitive K+ Channels: A Novel Strategy to Reduce the Deleterious Effects of Anoxia

  • Y. Ben-Ari
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 268)


Present strategies to reduce the deleterious effects of anoxia are essentially centered on the use of agents that block the effect of excitotoxic release of glutamate. Since the anoxie lesion is thought to result from excessive Ca++ influx at least partly through the NMDA receptor channel complex — (see Choi 1988) most present attempts have been made on the use of NMDA antagonists. These strategies include 1) blockers of NMDA receptor channel complex, and 2) blockers of the glycine allosteric site of NMDA receptors in order to reduce the action of glutamate on these receptors.


Input Resistance Kynurenic Acid Transient Cerebral Ischemia Electrogenic Pump Anoxic Depolarization 


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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Y. Ben-Ari
    • 1
  1. 1.INSERM Unité 29ParisFrance

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