NMDA-Receptors are Involved in Synaptic Plasticity Following Partial Denervation of CA1 Hippocampal Cells

  • Howard Wheal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 268)


Our original motive for partially denervating the CA1 pyramidal cells in the hippocampus was to try to separate the two major excitatory afferents onto these cells, the Schaffer collateral and commissural fibers, in order to explore whether they would independently supported long — term potentiation, LTP (Bliss et al, 1983; Wheal et a1,1983). The method that we used was that described by Nadler et al (1978), where the neurotoxin kainic acid was injected unilaterally into the lateral ventricle of the rat. This produced a specific loss of CA3/CA4 pyramidal cells in the hippocampus ipsilateral to the injection site (Nadler et al (1978), Lancaster andWheal,1982). In addition to the excitatory afferents onto the surviving CAl pyramidal cells showing potentiation, the cells themselves fired with graded bursts and also appeared to have lost some of their inhibitory responses (Lancaster andWhea1,1984).


NMDA Receptor Kainic Acid Epileptiform Activity Stratum Radiatum Schaffer Collateral 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Howard Wheal
    • 1
  1. 1.Department of NeurophysiologyUniversity of SouthamptonSouthamptonUK

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