Roles of Metabotropic and Ionotropic Glutamate Receptors in the Long-Term Potentiation of Hippocampal Mossy Fiber Synapses
Glutamate (Glu) is thought to be a major excitatory neurotransmitter in the central nervous system, and its receptors are believed to play important roles in brain functions such as learning and memory. For instance, Glu receptors of N-methyl-D-aspartate (NMDA) type are critically important in a certain form of synaptic long-term potentiation (LTP), which is a cellular or molecular model for memory. In other cases, however, in hippocampal mossy fiber synapses for instance, NMDA receptors may not be involved in the formation of LTP. The type of receptors involved there is not known.
KeywordsXenopus Oocyte Mossy Fiber Tetanic Stimulation Excitatory Amino Acid Receptor Stratum Lucidum
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