Roles of Metabotropic and Ionotropic Glutamate Receptors in the Long-Term Potentiation of Hippocampal Mossy Fiber Synapses

  • Hiroyuki Sugiyama
  • Isao Ito
  • Daisuke Okada
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 268)


Glutamate (Glu) is thought to be a major excitatory neurotransmitter in the central nervous system, and its receptors are believed to play important roles in brain functions such as learning and memory. For instance, Glu receptors of N-methyl-D-aspartate (NMDA) type are critically important in a certain form of synaptic long-term potentiation (LTP), which is a cellular or molecular model for memory. In other cases, however, in hippocampal mossy fiber synapses for instance, NMDA receptors may not be involved in the formation of LTP. The type of receptors involved there is not known.


Xenopus Oocyte Mossy Fiber Tetanic Stimulation Excitatory Amino Acid Receptor Stratum Lucidum 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Hiroyuki Sugiyama
    • 1
  • Isao Ito
    • 2
  • Daisuke Okada
    • 1
  1. 1.Department of Cellular PhysiologyNational Institute for Physiological SciencesOkazaki 444Japan
  2. 2.Fujigotemba Research LabsChugai Pharmaceutical CompanyGotemba 412Japan

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