Extracellular Proteases and S100 Protein in Long-Term Potentiation in the Dentate Gyrus of the Anaesthetized Rat

  • M. S. Fazeli
  • M. L. Errington
  • A. C. Dolphin
  • T. V. P. Bliss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 268)


The present chapter summarizes the results of experiments aimed at identifying macromolecules whose extracellular concentration is increased during long-term potentiation (LTP). The main approach has been sampling of extracellular fluid, using a push-pull cannula, before and after the induction of LTP.


Dentate Gyrus Spike Amplitude Protein Efflux Electrode Solution Extracellular Protease Activity 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • M. S. Fazeli
    • 1
  • M. L. Errington
    • 2
  • A. C. Dolphin
    • 1
  • T. V. P. Bliss
    • 2
  1. 1.Department of Pharmacology & Clinical PharmacologySt. George’s Hospital Medical SchoolLondonUK
  2. 2.Division of Neurophysiology and NeuropharmacologyNational Institute for Medical ResearchMill Hill, London NW10UK

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