Different Mechanisms and Multiple Stages of LTP

  • Hansjuergen Matthies
  • Uwe Frey
  • Klaus Reymann
  • Manfred Krug
  • Reinhard Jork
  • Helmut Schroeder
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 268)


On the basis of our own experimental data and results from other laboratories then available, we developed in 1972 a working hypothesis on neuronal mechanisms of memory. We suggested that the assumed stages of short-term, intermediate, and long-term memory, their different time course of origin and decay, their biochemical correlates as well as their sensitivity to interventions reflect the properties of the corresponding cellular mechanisms of a synaptic, synaptosomal and nuclear regulation of memory formation (Matthies, 1972).


Dentate Gyrus Perforant Path Impulse Train Train Interval Early Maintenance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Abraham, W.C., and Otani, S., 1988, Maintenance of long-term potentiation in the dentate gyrus requires protein synthesized shortly after tetanization in the anaesthetized rat, J.Physiol.(London) 407. 50 PGoogle Scholar
  2. Akers, R.F, Lovinger, D.M., Colley, P.A., Linden, D.J., and Routtenberg, A., 1986, Translocation of protein kinase C activity may mediate hippocampal long-term potentiation, Science, 231, 587PubMedCrossRefGoogle Scholar
  3. Bliss, T.V.P., Errington, M.L., Evan, G., and Hunt, S.P., 1988, Induction of c-fos like protein in rat hippocampus following electrical stimulation, J Physiol. (London), 398: 96 PGoogle Scholar
  4. Buzsaki, G. and Gage, F.H., 1989, Absence of long-term potentiation in the subcorticalìy deafferented dentate gyros, Brain Res. 484: 94PubMedCrossRefGoogle Scholar
  5. Charriaut-Marlangue, C., Aniksztein, L., Roisin, M.P., and Ben-Ary, Y., 1988, Release of proteins during long-term potentiation in the hippocampus of the anaesthetized rat, Neurosci.Lett. 91: 308PubMedCrossRefGoogle Scholar
  6. Chiarugi, V.P., Ruggiero, M., and Corradetti, R., 1989, Ontogenes, protein kinase C, neuronal differentiaation and memory, Neurochem.Int 14: 1PubMedCrossRefGoogle Scholar
  7. Collingridge, G.L., and Bliss, T.V.P., 1987. NMDA-receptors - their role in long-term potentiation, Trends Neurosci. 10: 288CrossRefGoogle Scholar
  8. Douglas, R.M., Dragunow, N., and Robertson, H.A., 1988, High-frequency discharge of dentate granule cells, but not long-term potentiation, induces c-fos protein, Moi.Brnin.Res. 4: 259CrossRefGoogle Scholar
  9. Dragunow, M., Abraham, W.C., Goulding, M., Mason, S.E., Robertson, H.a., and Fauii, R.L.M., 1989, Long-term potentiation and the induction of c-fos mRNA and proteins in the dentate gyrus of unanaesthetized rats, Neurosci.Lett. ???. 274Google Scholar
  10. Fazeli, M.S., Errington, M.L., Dolphiri, A.C., and Bliss, T.V.P., 1988 Longterm potentiation in the dentate gyrus of the anaesthetized rat is accompanied by an increase in protein efflux into push-pull cannula perfusates, Brain Ras 473: 51CrossRefGoogle Scholar
  11. Frey, U., Krug, M., Reymann, K., and Matthies, H., 1938, Anisomycin, an inhibitor of protein synthesis, blocks late phases of LIP phenomena in the hippocampal CA i region in vitro, Brain Res. 452: 57CrossRefGoogle Scholar
  12. Frey, U., Krug, M., Broedemann, R., Reymann, K.S., and Matthies, H., 1989, Longterm potentiation induced in dendrites separated from their CAI pyramidal somata does not establish a late phase, Neurosci.Lett. 97: 135PubMedCrossRefGoogle Scholar
  13. Frey, U., Hartmann, S., and Matthies, H., 1989, Domperidon, an inhibtor of the D2 - receptor, blocks a late phase of electrically induced long-term potentiation in the CA1 region in rats, Biomed.Biochem.Acta 48: 473Google Scholar
  14. Gispen, W.H., 1986, Synaptic protein phosphorylation and long-term potentiation, in Learning and Memory: Mechanisms of information storage in the nervous system, H. Matthies.ed., Pergamon Press, Oxford, p. 25Google Scholar
  15. Greenberg, M.E., Ziff, E.E., and Greene, L.A., 1986, Stimulation of neuronal acetylcholine receptors induces rapid gene transcription, Science 234: 80PubMedCrossRefGoogle Scholar
  16. Hanley, M.R. 1988, Proto-oncogenes in the nervous system, Neuron 1: 175PubMedCrossRefGoogle Scholar
  17. Hu, G.Y., Hvalby, O., Wsaiaas, S.I., Albert, K.A., Skjeflo, P., Andersen, P., and Greengard, P, 1997, Protein ninase C. injection into hippocampal pyramidal cells elicits features of long-term potentiation, Nature 328: 426CrossRefGoogle Scholar
  18. Jork, R., Grecksch, G., and Matthies, H., 1986, Impairment of gîycoproteir fucosylation in rat hippocampuss and the consequences on;memory formation, Pharmacol.Biochem.Behav. 25: 1137PubMedCrossRefGoogle Scholar
  19. Jork, R., Schnurra, I., Smalla, K.H., Grecksch, G., Popov, W., and Matthia, H., 1939, Deoxy-galactose mediate, amnesia. is related to an inhibition of training-induced increase in rat hippocampal glycoprotein fucosylaticn, Neurosci.Res.Commun. 5: 3Google Scholar
  20. Kaczmarek, L., Siedlecki, J.A., and Danysz, W., 1988, Proto-oncogene c-fos induction in rat hippocampus, Mol.Brain.Res. 3: 183CrossRefGoogle Scholar
  21. Kaczmarek, L., Nikolajew, E., Jakulski, D., Krug, M. Tischmeyer, W., and Matthies, H., 1989, Induction of c-fos protooncogene expression in rat nippocampus ocur ring in long-term potentiation and learning, submittedGoogle Scholar
  22. Krug, M., Loessner, B., and Ott, T., 1984, Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of reely moving rats, Brain Res.Bull. 13: 39PubMedCrossRefGoogle Scholar
  23. Loessner, B., Schweigert, C., Pchalek, V., Krug, M., Frey, S., and Matthies, H., 1987, Training and LIP-induced changes of protein synthesis in rat hippocampus. Neurosci. 22: S 512Google Scholar
  24. Malenka, R.C., Madison, D.V., and Nicoll, R.A. 1986, Potentiation of synaptic transmission in the hippocampus by phorbol esters, Nature 321: 175PubMedCrossRefGoogle Scholar
  25. Matthies, H., 1972, Pharmacological influence on teaching and memorization processes Farmakol. i.Toxikol. 35: 259Google Scholar
  26. Matthies, H., 1989a, Neurobiological aspects of learning and memory, Annu.Rev.Psychol. 40: 381PubMedCrossRefGoogle Scholar
  27. Matthies, H., 1989b, In search of cellular mechanisms of memory. Progr.Neurobiol. 32: 277CrossRefGoogle Scholar
  28. Nicoletti, F., Wroblewski, J.T., Fadda, E., and Costa, E., 1988, Pertussis toxin inhibits signal transduction at a specific metabolotropic glutamate receptor in primary cultures of cerebellar granule cells, Neuropharmacol. 27: 551CrossRefGoogle Scholar
  29. Otani, S., Marshall, C.J., Tate, W.P., Goddard, G.V., and Abraham, W.C., 1989, Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately posttetanication Neurosci. 28: 519CrossRefGoogle Scholar
  30. Pohle, W., Acosta, L., Ruethrich, H., Krug, M., and Matthies, H., 1987, Incorporation of 3H-fucose in rat hippocampal structures after conditioning by perforant path stimulation and after LIP-producing tetanization, Brain Res. 410: 245PubMedCrossRefGoogle Scholar
  31. Popov, N., Schulzeck, S., Schmidt, S., and Matthies, H., 1975, Changes in labeling of soluble and soiubilized rat brain proteins using 3H-leucine as precursor during a learning experiment, Acta 34: 583PubMedGoogle Scholar
  32. Popov, N.S., Reymann, K.G., Schulzech, K., Schulzeck, S., and Matthies, H., 1988, Alterations in calmodulin content in fractions of rat hippocampal slices during tetanic and calcium-induced long-term potentiation, Brain Res. Bull. 21: 201PubMedCrossRefGoogle Scholar
  33. Recasens, M., Guiramand, J., Nourigat, A., Sassetti, I., and Devilliers, G., 1989, A new quisqualate receptor subtype (sAA2) responsible for the glutamate-induced inositoi phosphate formation in rat brain synaptoneurosomes, Neurochem.Int. 13: 463CrossRefGoogle Scholar
  34. Reymann, K.G., Broedemann, R., Kase, H., and Matthies, H., 1988a, Inhibitors of calmodulin and protein kinase C block different phases of hippocampal long-term potentiation, Brain Res. 461: 388PubMedCrossRefGoogle Scholar
  35. Reymann, K.G., Frey, U., Jork, R., and Matthies, H., 1988b, Polymyxin B, an inhibitor of protein kinase C, prevents the maintenance of synaptic long-term potentiation in hippocampal CA1 neurons, Brain Res. 440: 305PubMedCrossRefGoogle Scholar
  36. Reymann, K.G., and Matthies, H., 1989a, 2-Amino-4-phosphonobutyrate selectively eliminates late phases of long-term potentiation in rat hippocampus, Neurosci.Lett., 98: 166CrossRefGoogle Scholar
  37. Reymann, K.G., Davies, S.N., Matthies, H., Kase, H., and Collingridge, G.L., 1989b, Activation of a K 252 b -sensitive protein kinase is necessary for a postsynaptic phase of long-term potentiation in area CA 1 of rat hippocampus, Eur. J. Neuroscí., submittedGoogle Scholar
  38. Robertson, G.S., Herrera, D.G., Dragunow, M., and Robertson, H.A., 1989, L-DORA activates c-fos in the striatum ipsilateral to a 6-hydroxydopamine lesion of the substantia nigra, Eur.J.Pharmacol. 159: 99PubMedCrossRefGoogle Scholar
  39. Routtenberg, A., 1987, Phosphoìipid and fatty acid regulation of signal transduction at synapses. potential role for protein kinase C in information storage, J.Neural Transm, 24 (Suppl.): 234Google Scholar
  40. Schoepp, D.D., and Johnson, B.G., 1988, Excitatory amino acid agonist-antagonist interactions at 2-amino-4-phosphonobutyric acid-sensitive quisqualate receptors coupled to phospho-inositide hydrolysis, J.Neurochem., 50: 1605PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Hansjuergen Matthies
    • 1
    • 2
  • Uwe Frey
    • 1
  • Klaus Reymann
    • 1
  • Manfred Krug
    • 2
  • Reinhard Jork
    • 1
  • Helmut Schroeder
    • 2
  1. 1.Institute of Neurobiology and Brain ResearchAcademy of SciencesMagdeburgGDR
  2. 2.Institute of PharmacologyMedical AcademyMagdeburgGDR

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