The Role of Protein Kinase C Substrate B-50 (GAP-43) in Neurotransmitter Release and Long-Term Potentiation

  • P. N. E. De Graan
  • L. H. Schrama
  • F. M. J. Heemskerk
  • L. V. Dekker
  • W. H. Gispen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 268)


Long-term potentiation (LTP) is a form of synaptic plasticity, which may be one of the events underlying learning and memory. LTP is triggered by brief, high-frequency stimulation of afferents, resulting in a long-lasting increase in the effectiveness of synaptic transmission (Bliss and Lomo, 1973; Bliss and Lynch, 1988; Brown et al., 1988; Matthies, 1989). Traditionally, LTP has been divided into two phases, the initiation phase and the maintenance phase. At present, three phases can be distinguished: (i) an initiation phase, including several seconds after tetanic stimulation when the events that trigger LTP begin; (ii) a transient phase, lasting about 30 min, during which there is a slow decay of potentiation, which can be evoked by local transmitter application without stimulating the presynaptic terminal; and (iii) a maintenance phase, which can last for hours (Kauer et al., 1988; Malinow et al., 1988a).


Hippocampal Slice Phorbol Ester Neurotransmitter Release Transmitter Release Population Spike 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • P. N. E. De Graan
    • 1
  • L. H. Schrama
    • 1
  • F. M. J. Heemskerk
    • 1
  • L. V. Dekker
    • 1
  • W. H. Gispen
    • 1
  1. 1.Division of Molecular Neurobiology, Rudolf Magnus Institute, Laboratory for Physiological ChemistryInstitute of Molecular Biology and Medical BiotechnologyUtrechtNL

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