Postsynaptic Mechanisms Involved in Long-Term Potentiation
Long-term potentiation (LTP) is a persistent enhancement of synaptic transmission observed at excitatory synapses in the mammalian hippocampus (Bliss and Lomo, 1973). This phenomenon is one of the most striking examples of synaptic plasticity in the vertebrate brain, and has been intensively studied as a model for learning and memory. LTP can be divided into two parts, the triggering or initiation events, and the long-lasting alteration in synaptic strength. In the past six years a considerable body of work has clarified some of the processes involved in triggering LTP, and it has become widely accepted that these processes are localized to the postsynaptic neuron. In contrast, the processes responsible for maintaining the potentiation over time are not as clearly understood, and the synaptic site of these processes remains controversial. This chapter will focus on work from our laboratory studying the cellular mechanisms involved in LTP at the Schaffer collateral-pyramidal cell synapse in the CA1 region of the hippocampal slice preparation.
KeywordsSynaptic Transmission Postsynaptic Neuron Postsynaptic Cell NMDA Channel NMDA Component
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