Abstract
In the mammalian cortex, glutamate (1) amd γ-aminobutyric acid (GABA) (2) are the principal transmitters mediating excitatory and inhibitory synaptic events. Glutamate activates cation conductances that lead to membrane depolarization. This action is mediated by at least three distinct receptor subtypes defined by their main agonists as N-methyl-D-aspartate (NMDA), quisqualate and kainate receptors (1). GABA controls at least two conductances that produce hyperpolarization in cortical neurons: an early inhibitory synaptic potential mediated by chloride currents through GABAA receptors (2) and a late hyperpolarization mediated by potassium current through GABAB receptors (3).
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References
Watkins, J.C. & Evans, R.H., Ann. Rev. Pharmacol. Tox. 21 165–204 (1981).
Krnjevic, K., Physiol.Rev. 54, 418–540 (1974).
Nicoll, R.A. & Alger, B.E. Science 212, 957–959 (1981).
Stelzer, A., Slater, N.T. & ten Bruggencate, G., Nature 326, 698–701 (1987).
Stelzer, A. & Wong, R.K.S., Nature 337, 170–173 (1989).
Slater, N.T., Stelzer, A., Galvan, M., Neurosci. Lett. 60, 25–31 (1985).
Stasheff, S.F., Bragdon, A.C. & Wilson, W.A., Brain Res. 344, 296–302 (1985).
MacDermott, A.B., Mayer, M.L, Westbrook, G.L., Smith, S.J. & Barker, J.L., Nature 321, 519–522 (1986).
Krnjevic, K, Morris, M.E. & Ropert, N., Brain Res. 374,1–11 (1986).
Stelzer, A., Kay, A.R. & Wong, R.K.S., Science 241, 339–341 (1988).
Chen, Q.X., Kay, A.R., Stelzer, A. & Wong, R.K.S., J. Physiol. (in press).
Olsen, R.W. & Venter, J.C., (eds.) Benzodiazepine/GABA Receptors and Chloride Channels: Structural and Functional Properties (Liss, New York, 1987).
Kay, A.R. & Wong, R.K.S., J. Neurosci. Meth. 16, 227–238 (1986).
Hamill, O.P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F.J., Pfluegers Arch. ges. Physiol. 391, 85–100 (1981).
Kiskin, N.I., Krishtal, O.A. & Tsyndrenko, A.Y., Neurosci. Lett. 63, 225–230 (1986).
Stelzer, A. & Wong, R.K.S., Soc. Neurosci. Abstr. 369.2 (1988).
Sigel, E. & Baur, R., Proc. Natl. Acad.Sci. USA 86,2938–2942 (1988).
Browning et al., Soc. Neurosci. Abstr. (1989).
Nishizuka, Y., Science 233, 305–312 (1986).
Kaibuchi, K. et al., Cell Calcium 3, 323 (1982).
Castagna, M. et al., J. Biol. Chem. 257, 7847 (1982).
Doerner, D., Pitler, T.A. & Alger, B.E., J. Neurosci. 8(11), 4069–4078 (1988).
Ferraro, T.N. & Hare, T.A., Brain Res. 338, 53–60 (1985).
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Stelzer, A. (1990). Regulation of GABAA Currents by Excitatory Amino Acids. In: Ben-Ari, Y. (eds) Excitatory Amino Acids and Neuronal Plasticity. Advances in Experimental Medicine and Biology, vol 268. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5769-8_29
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DOI: https://doi.org/10.1007/978-1-4684-5769-8_29
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